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Chirped guided-mode resonance biosensor

Advanced biomedical diagnostic technologies fulfill an important role in improving health and well-being in society. A large number of excellent technologies have already been introduced and have given rise to the “lab-on-a-chip” paradigm. Most of these technologies, however, require additional inst...

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Autores principales: Triggs, Graham J., Wang, Yue, Reardon, Christopher P., Fischer, Matthias, Evans, Gareth J. O., Krauss, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513287/
https://www.ncbi.nlm.nih.gov/pubmed/31149627
http://dx.doi.org/10.1364/OPTICA.4.000229
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author Triggs, Graham J.
Wang, Yue
Reardon, Christopher P.
Fischer, Matthias
Evans, Gareth J. O.
Krauss, Thomas F.
author_facet Triggs, Graham J.
Wang, Yue
Reardon, Christopher P.
Fischer, Matthias
Evans, Gareth J. O.
Krauss, Thomas F.
author_sort Triggs, Graham J.
collection PubMed
description Advanced biomedical diagnostic technologies fulfill an important role in improving health and well-being in society. A large number of excellent technologies have already been introduced and have given rise to the “lab-on-a-chip” paradigm. Most of these technologies, however, require additional instrumentation for interfacing and readout, so they are often confined to the laboratory and are not suitable for use in the field or in wider clinical practice. Other technologies require a light coupling element, such as a grating coupler or a fiber coupler, which complicates packaging. Here, we introduce a novel biosensor based on a chirped guided-mode resonant grating. The chirped grating combines the sensing function with the readout function by translating spectral information into spatial information that is easily read out with a simple CMOS camera. We demonstrate a refractive index sensitivity of 137 nm/RIU and an extrapolated limit of detection of 267 pM for the specific binding of an immunoglobulin G antibody. The chirped guided-mode resonance approach introduces a new degree of freedom for sensing biomedical information that combines high sensitivity with autonomous operation. We estimate that the cost of components is U.S. $10 or less when mass manufactured, so the technology has the potential to truly transform point-of-care applications.
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spelling pubmed-65132872019-05-28 Chirped guided-mode resonance biosensor Triggs, Graham J. Wang, Yue Reardon, Christopher P. Fischer, Matthias Evans, Gareth J. O. Krauss, Thomas F. Optica Article Advanced biomedical diagnostic technologies fulfill an important role in improving health and well-being in society. A large number of excellent technologies have already been introduced and have given rise to the “lab-on-a-chip” paradigm. Most of these technologies, however, require additional instrumentation for interfacing and readout, so they are often confined to the laboratory and are not suitable for use in the field or in wider clinical practice. Other technologies require a light coupling element, such as a grating coupler or a fiber coupler, which complicates packaging. Here, we introduce a novel biosensor based on a chirped guided-mode resonant grating. The chirped grating combines the sensing function with the readout function by translating spectral information into spatial information that is easily read out with a simple CMOS camera. We demonstrate a refractive index sensitivity of 137 nm/RIU and an extrapolated limit of detection of 267 pM for the specific binding of an immunoglobulin G antibody. The chirped guided-mode resonance approach introduces a new degree of freedom for sensing biomedical information that combines high sensitivity with autonomous operation. We estimate that the cost of components is U.S. $10 or less when mass manufactured, so the technology has the potential to truly transform point-of-care applications. Optical Society of America 2017-02-13 /pmc/articles/PMC6513287/ /pubmed/31149627 http://dx.doi.org/10.1364/OPTICA.4.000229 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. 2334-2536/17/020229-06
spellingShingle Article
Triggs, Graham J.
Wang, Yue
Reardon, Christopher P.
Fischer, Matthias
Evans, Gareth J. O.
Krauss, Thomas F.
Chirped guided-mode resonance biosensor
title Chirped guided-mode resonance biosensor
title_full Chirped guided-mode resonance biosensor
title_fullStr Chirped guided-mode resonance biosensor
title_full_unstemmed Chirped guided-mode resonance biosensor
title_short Chirped guided-mode resonance biosensor
title_sort chirped guided-mode resonance biosensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513287/
https://www.ncbi.nlm.nih.gov/pubmed/31149627
http://dx.doi.org/10.1364/OPTICA.4.000229
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