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ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD

Photodynamic diagnosis/therapy (PDD/PDT) are novel modalities for the diagnosis and treatment of cancer. The photosensitizer protoporphyrin IX is metabolized from 5-aminolevulinic acid (5-ALA) intracellularly, and PDD/PDT using 5-ALA have been approved in dermatologic malignancies and gliomas. Howev...

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Detalles Bibliográficos
Autores principales:	Kawai, Noriko, Hirohashi, Yoshihiko, Ebihara, Yuma, Saito, Takuma, Murai, Aiko, Saito, Takahiro, Shirosaki, Tomohide, Kubo, Terufumi, Nakatsugawa, Munehide, Kanaseki, Takayuki, Tsukahara, Tomohide, Shichinohe, Toshiaki, Li, Liming, Hirano, Satoshi, Torigoe, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513434/ https://www.ncbi.nlm.nih.gov/pubmed/31083682 http://dx.doi.org/10.1371/journal.pone.0216503

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