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Preoperative systemic inflammatory markers in low- and high-grade gliomas: A retrospective analysis of 171 patients

PURPOSE: Preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) are recognized as prognostic markers of grade of gliomas. The aim of this study was to determine whether preoperative levels of NLR, PLR, and LMR differ between low- and high-...

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Detalles Bibliográficos
Autores principales: Kemerdere, Rahsan, Akgun, Mehmet Yigit, Toklu, Sureyya, Alizada, Orkhan, Tanriverdi, Taner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513782/
https://www.ncbi.nlm.nih.gov/pubmed/31193037
http://dx.doi.org/10.1016/j.heliyon.2019.e01681
Descripción
Sumario:PURPOSE: Preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) are recognized as prognostic markers of grade of gliomas. The aim of this study was to determine whether preoperative levels of NLR, PLR, and LMR differ between low- and high-grade gliomas. METHODS: Retrospective analysis of preoperative neutrophil, lymphocyte, monocyte, and platelet counts and NLR, PLR, and LMR were performed in 171 patients who underwent glioma surgery. The results were compared between low- and high-grade gliomas. RESULTS: Neutrophil count was significantly increased while lymphocyte count significantly decreased in high-grade gliomas (HGGs). NLR and PLR were significantly higher in HGGs but LMR was significantly reduced in HGGs. NLR and PLR correlated with glioma grade and only NLR showed highest accuracy predicting higher grade. CONCLUSIONS: Levels of preoperative NLR value can help to evaluate disease progression and predict higher grade of glioma.