Meiotic spindle assembly checkpoint and aneuploidy in males versus females

The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the pr...

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Detalles Bibliográficos
Autores principales: Lane, Simon, Kauppi, Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513798/
https://www.ncbi.nlm.nih.gov/pubmed/30564841
http://dx.doi.org/10.1007/s00018-018-2986-6
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author Lane, Simon
Kauppi, Liisa
author_facet Lane, Simon
Kauppi, Liisa
author_sort Lane, Simon
collection PubMed
description The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.
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spelling pubmed-65137982019-05-28 Meiotic spindle assembly checkpoint and aneuploidy in males versus females Lane, Simon Kauppi, Liisa Cell Mol Life Sci Review The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes. Springer International Publishing 2018-12-18 2019 /pmc/articles/PMC6513798/ /pubmed/30564841 http://dx.doi.org/10.1007/s00018-018-2986-6 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Lane, Simon
Kauppi, Liisa
Meiotic spindle assembly checkpoint and aneuploidy in males versus females
title Meiotic spindle assembly checkpoint and aneuploidy in males versus females
title_full Meiotic spindle assembly checkpoint and aneuploidy in males versus females
title_fullStr Meiotic spindle assembly checkpoint and aneuploidy in males versus females
title_full_unstemmed Meiotic spindle assembly checkpoint and aneuploidy in males versus females
title_short Meiotic spindle assembly checkpoint and aneuploidy in males versus females
title_sort meiotic spindle assembly checkpoint and aneuploidy in males versus females
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513798/
https://www.ncbi.nlm.nih.gov/pubmed/30564841
http://dx.doi.org/10.1007/s00018-018-2986-6
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