Flu DRiPs in MHC Class I Immunosurveillance

Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8(+) T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from...

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Detalles Bibliográficos
Autores principales: Wei, Jiajie, Yewdell, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513827/
https://www.ncbi.nlm.nih.gov/pubmed/30456657
http://dx.doi.org/10.1007/s12250-018-0061-y
Descripción
Sumario:Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8(+) T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead.

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