Flu DRiPs in MHC Class I Immunosurveillance

Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8(+) T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from...

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Detalles Bibliográficos
Autores principales: Wei, Jiajie, Yewdell, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513827/
https://www.ncbi.nlm.nih.gov/pubmed/30456657
http://dx.doi.org/10.1007/s12250-018-0061-y
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author Wei, Jiajie
Yewdell, Jonathan W.
author_facet Wei, Jiajie
Yewdell, Jonathan W.
author_sort Wei, Jiajie
collection PubMed
description Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8(+) T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead.
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spelling pubmed-65138272019-05-28 Flu DRiPs in MHC Class I Immunosurveillance Wei, Jiajie Yewdell, Jonathan W. Virol Sin Review Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8(+) T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead. Springer Singapore 2018-11-19 /pmc/articles/PMC6513827/ /pubmed/30456657 http://dx.doi.org/10.1007/s12250-018-0061-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Wei, Jiajie
Yewdell, Jonathan W.
Flu DRiPs in MHC Class I Immunosurveillance
title Flu DRiPs in MHC Class I Immunosurveillance
title_full Flu DRiPs in MHC Class I Immunosurveillance
title_fullStr Flu DRiPs in MHC Class I Immunosurveillance
title_full_unstemmed Flu DRiPs in MHC Class I Immunosurveillance
title_short Flu DRiPs in MHC Class I Immunosurveillance
title_sort flu drips in mhc class i immunosurveillance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513827/
https://www.ncbi.nlm.nih.gov/pubmed/30456657
http://dx.doi.org/10.1007/s12250-018-0061-y
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