GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

Drug resistance diagnostics that rely on the detection of resistance-related mutations could expedite patient care and TB eradication. We perform minimum inhibitory concentration testing for 12 anti-TB drugs together with Illumina whole-genome sequencing on 1452 clinical Mycobacterium tuberculosis (...

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Detalles Bibliográficos
Autores principales: Farhat, Maha R., Freschi, Luca, Calderon, Roger, Ioerger, Thomas, Snyder, Matthew, Meehan, Conor J., de Jong, Bouke, Rigouts, Leen, Sloutsky, Alex, Kaur, Devinder, Sunyaev, Shamil, van Soolingen, Dick, Shendure, Jay, Sacchettini, Jim, Murray, Megan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513847/
https://www.ncbi.nlm.nih.gov/pubmed/31086182
http://dx.doi.org/10.1038/s41467-019-10110-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513847/
https://www.ncbi.nlm.nih.gov/pubmed/31086182
http://dx.doi.org/10.1038/s41467-019-10110-6

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