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Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial pathology characterized by amyloid deposits, neurofibrillary formation, oxidative stress and cholinergic system dysfunction. In this sense, here we report the rational design of a multi-target directed ligand (MTDL) for AD based on virtual screening and b...

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Detalles Bibliográficos
Autores principales:	Fronza, Mariana G., Baldinotti, Rodolfo, Martins, Maria Clara, Goldani, Bruna, Dalberto, Bianca Thaís, Kremer, Frederico Schmitt, Begnini, Karine, Pinto, Luciano da Silva, Lenardão, Eder João, Seixas, Fabiana K., Collares, Tiago, Alves, Diego, Savegnago, Lucielli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513848/ https://www.ncbi.nlm.nih.gov/pubmed/31086208 http://dx.doi.org/10.1038/s41598-019-43532-9

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