Synthetic biology strategies for microbial biosynthesis of plant natural products

Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts...

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Detalles Bibliográficos
Autores principales: Cravens, Aaron, Payne, James, Smolke, Christina D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513858/
https://www.ncbi.nlm.nih.gov/pubmed/31086174
http://dx.doi.org/10.1038/s41467-019-09848-w
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author Cravens, Aaron
Payne, James
Smolke, Christina D.
author_facet Cravens, Aaron
Payne, James
Smolke, Christina D.
author_sort Cravens, Aaron
collection PubMed
description Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts requires finding or modifying a suitable host to accommodate the pathway, planning and implementing a biosynthetic route to the compound, and discovering or engineering enzymes for missing steps. In this review, we describe recent developments in metabolic engineering at the level of host, pathway, and enzyme, and discuss how the field is approaching ever more complex biosynthetic opportunities.
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spelling pubmed-65138582019-05-15 Synthetic biology strategies for microbial biosynthesis of plant natural products Cravens, Aaron Payne, James Smolke, Christina D. Nat Commun Review Article Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts requires finding or modifying a suitable host to accommodate the pathway, planning and implementing a biosynthetic route to the compound, and discovering or engineering enzymes for missing steps. In this review, we describe recent developments in metabolic engineering at the level of host, pathway, and enzyme, and discuss how the field is approaching ever more complex biosynthetic opportunities. Nature Publishing Group UK 2019-05-13 /pmc/articles/PMC6513858/ /pubmed/31086174 http://dx.doi.org/10.1038/s41467-019-09848-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Cravens, Aaron
Payne, James
Smolke, Christina D.
Synthetic biology strategies for microbial biosynthesis of plant natural products
title Synthetic biology strategies for microbial biosynthesis of plant natural products
title_full Synthetic biology strategies for microbial biosynthesis of plant natural products
title_fullStr Synthetic biology strategies for microbial biosynthesis of plant natural products
title_full_unstemmed Synthetic biology strategies for microbial biosynthesis of plant natural products
title_short Synthetic biology strategies for microbial biosynthesis of plant natural products
title_sort synthetic biology strategies for microbial biosynthesis of plant natural products
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513858/
https://www.ncbi.nlm.nih.gov/pubmed/31086174
http://dx.doi.org/10.1038/s41467-019-09848-w
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