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Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling

Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) via its soluble IL-6R (sIL-6R) has been termed trans-signaling and is thought to be responsible for the pro-inflammatory properties of IL-6. The sIL-6R can be generated by alternative mRNA splicing or proteolytic cleavage of the membrane-bou...

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Detalles Bibliográficos
Autores principales:	Flynn, Charlotte M., Garbers, Yvonne, Lokau, Juliane, Wesch, Daniela, Schulte, Dominik M., Laudes, Matthias, Lieb, Wolfgang, Aparicio-Siegmund, Samadhi, Garbers, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513869/ https://www.ncbi.nlm.nih.gov/pubmed/31086276 http://dx.doi.org/10.1038/s41598-019-43617-5

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