Cargando…

A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs

Chromosomal maintenance 1 (CRM1) inhibitors display antihypertrophic effects and control protein trafficking between the nucleus and the cytoplasm. PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1alpha) is a type of transcriptional coactivator that predominantly resides in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zuheng, Tian, Haiping, Hua, Jinghai, Cai, Wanqiang, Bai, Yujia, Zhan, Qiong, Lai, Wenyan, Zeng, Qingchun, Ren, Hao, Xu, Dingli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513890/ https://www.ncbi.nlm.nih.gov/pubmed/31133853 http://dx.doi.org/10.3389/fphar.2019.00465

Ejemplares similares

N-terminal truncated peroxisome proliferator-activated receptor-γ coactivator-1α alleviates phenylephrine-induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes
por: Liu, Zuheng, et al.
Publicado: (2018)

Metformin Increases Cardiac Rupture After Myocardial Infarction via the AMPK-MTOR/PGC-1α Signaling Pathway in Rats with Acute Myocardial Infarction
por: Hua, Jinghai, et al.
Publicado: (2018)

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury
por: Xiong, Wenjun, et al.
Publicado: (2019)

Effect of patterned polyacrylamide hydrogel on morphology and orientation of cultured NRVMs
por: Sanzari, I., et al.
Publicado: (2018)

Association of Urine Albumin/Creatinine Ratio below 30 mg/g and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes
por: Xie, Xiangkun, et al.
Publicado: (2020)

Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice
por: Liu, Zuheng, et al.
Publicado: (2017)

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue
por: Chang, Ji Suk, et al.
Publicado: (2018)

Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism
por: Jun, Hee-Jin, et al.
Publicado: (2012)

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α
por: Kim, Jihyun, et al.
Publicado: (2016)

Induction of the ER stress response in NRVMs is linked to cardiotoxicity caused by celastrol: Celastrol cardiotoxicity involves the ER stress response
por: Chen, Zhong, et al.
Publicado: (2022)

The truncated splice variants, NT-PGC-1α and PGC-1α4, increase with both endurance and resistance exercise in human skeletal muscle
por: Ydfors, Mia, et al.
Publicado: (2013)

The Interaction of CRM1 and the Nuclear Pore Protein Tpr
por: Zhao, Charles L., et al.
Publicado: (2014)

Transcriptional coactivator NT‐PGC‐1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis
por: Chang, Ji Suk, et al.
Publicado: (2016)

Correlation of CRM1-NES affinity with nuclear export activity
por: Fu, Szu-Chin, et al.
Publicado: (2018)

Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study
por: Peng, Zhengliang, et al.
Publicado: (2019)

CRM1 Inhibitors for Antiviral Therapy
por: Mathew, Cynthia, et al.
Publicado: (2017)

Small Molecule Inhibitors of CRM1
por: Ferreira, Bibiana I., et al.
Publicado: (2020)

PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury
por: Yuan, Longhui, et al.
Publicado: (2021)

Nxt1 Is Necessary for the Terminal Step of Crm1-Mediated Nuclear Export
por: Black, Ben E., et al.
Publicado: (2001)

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer
por: Sexton, Rachel, et al.
Publicado: (2019)

Effect of Exercise Intensity on Isoform-Specific Expressions of NT-PGC-1 α mRNA in Mouse Skeletal Muscle
por: Wen, Xingyuan, et al.
Publicado: (2014)

CRM1-mediated Recycling of Snurportin 1 to the Cytoplasm
por: Paraskeva, Efrosyni, et al.
Publicado: (1999)

Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
por: Ederle, Helena, et al.
Publicado: (2018)

CRM for dummies
por: Helgeson, Lars
Publicado: (2017)

CRM Fundamentals
por: Kostojohn, Scott
Publicado: (2011)

Crm1 locks up replication factors
por: Tuma, Rabiya S.
Publicado: (2003)

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
por: Fung, Ho Yee Joyce, et al.
Publicado: (2017)

Protein Kinase SGK2 Is Induced by the β(3) Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis
por: Park, Chul-Hong, et al.
Publicado: (2021)

Structural determinants of nuclear export signal orientation in binding to exportin CRM1
por: Fung, Ho Yee Joyce, et al.
Publicado: (2015)

NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity
por: Zhang, Xin, et al.
Publicado: (2020)

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition
por: Azmi, Asfar S., et al.
Publicado: (2015)

Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function
por: Ma, Zhuang, et al.
Publicado: (2023)

Structural Basis of Targeting the Exportin CRM1 in Cancer
por: Dickmanns, Achim, et al.
Publicado: (2015)

An update to the CRM1 cargo/NES database NESdb
por: Fung, Ho Yee Joyce, et al.
Publicado: (2021)

CRM para directivos /
por: Anderson, Kristin, 1962-
Publicado: (2003)

CRM Workshop on Moonshine
por: Collective
Publicado: (1999)

SugarCRM for dummies
por: Fredricks, Karen S
Publicado: (2009)

Building on SugarCRM
por: Mertic, John
Publicado: (2011)

DI/CRM Workshop
Publicado: (2000)

Using Microsoft CRM
por: Brown, Laura, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_rovbsbqvlisr8tq49srvgmcgfa