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Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
Polycomb (PcG) and Trithorax (TrxG) group proteins give stable epigenetic memory of silent and active gene expression states, but also allow poised states in pluripotent cells. Here we systematically address the relationship between poised, active and silent chromatin, by integrating 73 publications...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513952/ https://www.ncbi.nlm.nih.gov/pubmed/31086177 http://dx.doi.org/10.1038/s41467-019-10130-2 |