Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis

Liver fibrosis is characterised by a dense and highly cross-linked extracellular matrix (ECM) which promotes progression of diseases such as hepatocellular carcinoma. The fibrotic microenvironment is characterised by an increased stiffness, with rigidity associated with disease progression. External...

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Detalles Bibliográficos
Autores principales: Lachowski, Dariusz, Cortes, Ernesto, Rice, Alistair, Pinato, David, Rombouts, Krista, del Rio Hernandez, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514003/
https://www.ncbi.nlm.nih.gov/pubmed/31086224
http://dx.doi.org/10.1038/s41598-019-43759-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514003/
https://www.ncbi.nlm.nih.gov/pubmed/31086224
http://dx.doi.org/10.1038/s41598-019-43759-6

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