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Pathological effects of ionizing radiation: endothelial activation and dysfunction

The endothelium, a tissue that forms a single layer of cells lining various organs and cavities of the body, especially the heart and blood as well as lymphatic vessels, plays a complex role in vascular biology. It contributes to key aspects of vascular homeostasis and is also involved in pathophysi...

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Detalles Bibliográficos
Autores principales: Baselet, Bjorn, Sonveaux, Pierre, Baatout, Sarah, Aerts, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514067/
https://www.ncbi.nlm.nih.gov/pubmed/30377700
http://dx.doi.org/10.1007/s00018-018-2956-z
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author Baselet, Bjorn
Sonveaux, Pierre
Baatout, Sarah
Aerts, An
author_facet Baselet, Bjorn
Sonveaux, Pierre
Baatout, Sarah
Aerts, An
author_sort Baselet, Bjorn
collection PubMed
description The endothelium, a tissue that forms a single layer of cells lining various organs and cavities of the body, especially the heart and blood as well as lymphatic vessels, plays a complex role in vascular biology. It contributes to key aspects of vascular homeostasis and is also involved in pathophysiological processes, such as thrombosis, inflammation, and hypertension. Epidemiological data show that high doses of ionizing radiation lead to cardiovascular disease over time. The aim of this review is to summarize the current knowledge on endothelial cell activation and dysfunction after ionizing radiation exposure as a central feature preceding the development of cardiovascular diseases.
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spelling pubmed-65140672019-05-28 Pathological effects of ionizing radiation: endothelial activation and dysfunction Baselet, Bjorn Sonveaux, Pierre Baatout, Sarah Aerts, An Cell Mol Life Sci Review The endothelium, a tissue that forms a single layer of cells lining various organs and cavities of the body, especially the heart and blood as well as lymphatic vessels, plays a complex role in vascular biology. It contributes to key aspects of vascular homeostasis and is also involved in pathophysiological processes, such as thrombosis, inflammation, and hypertension. Epidemiological data show that high doses of ionizing radiation lead to cardiovascular disease over time. The aim of this review is to summarize the current knowledge on endothelial cell activation and dysfunction after ionizing radiation exposure as a central feature preceding the development of cardiovascular diseases. Springer International Publishing 2018-10-30 2019 /pmc/articles/PMC6514067/ /pubmed/30377700 http://dx.doi.org/10.1007/s00018-018-2956-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Baselet, Bjorn
Sonveaux, Pierre
Baatout, Sarah
Aerts, An
Pathological effects of ionizing radiation: endothelial activation and dysfunction
title Pathological effects of ionizing radiation: endothelial activation and dysfunction
title_full Pathological effects of ionizing radiation: endothelial activation and dysfunction
title_fullStr Pathological effects of ionizing radiation: endothelial activation and dysfunction
title_full_unstemmed Pathological effects of ionizing radiation: endothelial activation and dysfunction
title_short Pathological effects of ionizing radiation: endothelial activation and dysfunction
title_sort pathological effects of ionizing radiation: endothelial activation and dysfunction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514067/
https://www.ncbi.nlm.nih.gov/pubmed/30377700
http://dx.doi.org/10.1007/s00018-018-2956-z
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