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Extracellular Vesicles: Delivery Vehicles of Myokines
Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514434/ https://www.ncbi.nlm.nih.gov/pubmed/31133872 http://dx.doi.org/10.3389/fphys.2019.00522 |
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author | Trovato, Eleonora Di Felice, Valentina Barone, Rosario |
author_facet | Trovato, Eleonora Di Felice, Valentina Barone, Rosario |
author_sort | Trovato, Eleonora |
collection | PubMed |
description | Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the blood stream, and are able to mediate beneficial effects throughout the whole body. In particular, contracting skeletal muscle cells have the capacity to communicate with other organs through the release of humoral factors that play an important role in the mechanisms of adaptation to physical exercise. These muscle-derived factors, today recognized as myokines, act as endocrine and paracrine hormones. Moreover, exercise may stimulate the release of small membranous vesicles into circulation, whose composition is influenced by the same exercise. Combining the two hypotheses, these molecules related to exercise, named exer-kines, might be secreted from muscle cells inside small vesicles (nanovesicles). These could act as messengers in tissue cross talk during physical exercise. Thanks to their ability to deliver useful molecules (such as proteins and miRNA) in both physiological and pathological conditions, extracellular vesicles can be thought of as promising candidates for potential therapeutic and diagnostic applications for several diseases. |
format | Online Article Text |
id | pubmed-6514434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65144342019-05-27 Extracellular Vesicles: Delivery Vehicles of Myokines Trovato, Eleonora Di Felice, Valentina Barone, Rosario Front Physiol Physiology Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the blood stream, and are able to mediate beneficial effects throughout the whole body. In particular, contracting skeletal muscle cells have the capacity to communicate with other organs through the release of humoral factors that play an important role in the mechanisms of adaptation to physical exercise. These muscle-derived factors, today recognized as myokines, act as endocrine and paracrine hormones. Moreover, exercise may stimulate the release of small membranous vesicles into circulation, whose composition is influenced by the same exercise. Combining the two hypotheses, these molecules related to exercise, named exer-kines, might be secreted from muscle cells inside small vesicles (nanovesicles). These could act as messengers in tissue cross talk during physical exercise. Thanks to their ability to deliver useful molecules (such as proteins and miRNA) in both physiological and pathological conditions, extracellular vesicles can be thought of as promising candidates for potential therapeutic and diagnostic applications for several diseases. Frontiers Media S.A. 2019-05-07 /pmc/articles/PMC6514434/ /pubmed/31133872 http://dx.doi.org/10.3389/fphys.2019.00522 Text en Copyright © 2019 Trovato, Di Felice and Barone. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Trovato, Eleonora Di Felice, Valentina Barone, Rosario Extracellular Vesicles: Delivery Vehicles of Myokines |
title | Extracellular Vesicles: Delivery Vehicles of Myokines |
title_full | Extracellular Vesicles: Delivery Vehicles of Myokines |
title_fullStr | Extracellular Vesicles: Delivery Vehicles of Myokines |
title_full_unstemmed | Extracellular Vesicles: Delivery Vehicles of Myokines |
title_short | Extracellular Vesicles: Delivery Vehicles of Myokines |
title_sort | extracellular vesicles: delivery vehicles of myokines |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514434/ https://www.ncbi.nlm.nih.gov/pubmed/31133872 http://dx.doi.org/10.3389/fphys.2019.00522 |
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