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Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of cytosolic pyruvate to mitochondrial acetyl-CoA,...

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Detalles Bibliográficos
Autores principales:	Min, Byong-Keol, Park, Sungmi, Kang, Hyeon-Ji, Kim, Dong Wook, Ham, Hye Jin, Ha, Chae-Myeong, Choi, Byung-Jun, Lee, Jung Yi, Oh, Chang Joo, Yoo, Eun Kyung, Kim, Hui Eon, Kim, Byung-Gyu, Jeon, Jae-Han, Hyeon, Do Young, Hwang, Daehee, Kim, Yong-Hoon, Lee, Chul-Ho, Lee, Taeho, Kim, Jung-whan, Choi, Yeon-Kyung, Park, Keun-Gyu, Chawla, Ajay, Lee, Jongsoon, Harris, Robert A., Lee, In-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514528/ https://www.ncbi.nlm.nih.gov/pubmed/31134063 http://dx.doi.org/10.3389/fimmu.2019.00944

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