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Structural and functional consequences of age-related isomerization in α-crystallins

Long-lived proteins are subject to spontaneous degradation and may accumulate a range of modifications over time, including subtle alterations such as side-chain isomerization. Recently, tandem MS has enabled identification and characterization of such peptide isomers, including those differing only...

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Detalles Bibliográficos
Autores principales:	Lyon, Yana A., Collier, Miranda P., Riggs, Dylan L., Degiacomi, Matteo T., Benesch, Justin L. P., Julian, Ryan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514633/ https://www.ncbi.nlm.nih.gov/pubmed/30804217 http://dx.doi.org/10.1074/jbc.RA118.007052

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