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C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression

Cancer is a leading cause of death and disease worldwide, with a tremendous financial impact. Thus, the development of cost-effective novel approaches for suppressing tumor growth and progression is essential. In an attempt to identify the mechanisms responsible for tumor suppression, we screened fo...

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Autores principales: Yang, Xiao-Yan, Ozawa, Shigeyuki, Kato, Yasumasa, Maehata, Yojiro, Izukuri, Kazuhito, Ikoma, Takeharu, Kanamori, Keisuke, Akasaka, Tetsu, Suzuki, Kenji, Iwabuchi, Hiroshi, Kurata, Shun-Ichi, Katoh, Iyoko, Sakurai, Takashi, Kiyono, Tohru, Hata, Ryu-Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514660/
https://www.ncbi.nlm.nih.gov/pubmed/31014014
http://dx.doi.org/10.3390/ijms20081872
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author Yang, Xiao-Yan
Ozawa, Shigeyuki
Kato, Yasumasa
Maehata, Yojiro
Izukuri, Kazuhito
Ikoma, Takeharu
Kanamori, Keisuke
Akasaka, Tetsu
Suzuki, Kenji
Iwabuchi, Hiroshi
Kurata, Shun-Ichi
Katoh, Iyoko
Sakurai, Takashi
Kiyono, Tohru
Hata, Ryu-Ichiro
author_facet Yang, Xiao-Yan
Ozawa, Shigeyuki
Kato, Yasumasa
Maehata, Yojiro
Izukuri, Kazuhito
Ikoma, Takeharu
Kanamori, Keisuke
Akasaka, Tetsu
Suzuki, Kenji
Iwabuchi, Hiroshi
Kurata, Shun-Ichi
Katoh, Iyoko
Sakurai, Takashi
Kiyono, Tohru
Hata, Ryu-Ichiro
author_sort Yang, Xiao-Yan
collection PubMed
description Cancer is a leading cause of death and disease worldwide, with a tremendous financial impact. Thus, the development of cost-effective novel approaches for suppressing tumor growth and progression is essential. In an attempt to identify the mechanisms responsible for tumor suppression, we screened for molecules downregulated in a cancer progression model and found that the chemokine CXCL14, also called BRAK, was the most significantly downregulated. Increasing the production of CXCL14 protein by transfecting tumor cells with a CXCL14 expression vector and transplanting the cells into the back skin of immunodeficient mice suppressed tumor cell growth compared with that of parental tumor cells, suggesting that CXCL14 suppressed tumor growth in vivo. However, some studies have reported that over-expression of CXCL14, especially in stromal cells, stimulated the progression of tumor formation. Transgenic mice expressing 10-fold more CXCL14 protein than wild-type C57BL/6 mice showed reduced rates of chemical carcinogenesis, transplanted tumor growth, and metastasis without apparent side effects. CXCL14 also acts as an antimicrobial molecule. In this review, we highlight recent studies involving the identification and characterization of CXCL14 in cancer progression and discuss the reasons for the context-dependent effects of CXCL14 on tumor formation.
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spelling pubmed-65146602019-05-30 C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression Yang, Xiao-Yan Ozawa, Shigeyuki Kato, Yasumasa Maehata, Yojiro Izukuri, Kazuhito Ikoma, Takeharu Kanamori, Keisuke Akasaka, Tetsu Suzuki, Kenji Iwabuchi, Hiroshi Kurata, Shun-Ichi Katoh, Iyoko Sakurai, Takashi Kiyono, Tohru Hata, Ryu-Ichiro Int J Mol Sci Review Cancer is a leading cause of death and disease worldwide, with a tremendous financial impact. Thus, the development of cost-effective novel approaches for suppressing tumor growth and progression is essential. In an attempt to identify the mechanisms responsible for tumor suppression, we screened for molecules downregulated in a cancer progression model and found that the chemokine CXCL14, also called BRAK, was the most significantly downregulated. Increasing the production of CXCL14 protein by transfecting tumor cells with a CXCL14 expression vector and transplanting the cells into the back skin of immunodeficient mice suppressed tumor cell growth compared with that of parental tumor cells, suggesting that CXCL14 suppressed tumor growth in vivo. However, some studies have reported that over-expression of CXCL14, especially in stromal cells, stimulated the progression of tumor formation. Transgenic mice expressing 10-fold more CXCL14 protein than wild-type C57BL/6 mice showed reduced rates of chemical carcinogenesis, transplanted tumor growth, and metastasis without apparent side effects. CXCL14 also acts as an antimicrobial molecule. In this review, we highlight recent studies involving the identification and characterization of CXCL14 in cancer progression and discuss the reasons for the context-dependent effects of CXCL14 on tumor formation. MDPI 2019-04-16 /pmc/articles/PMC6514660/ /pubmed/31014014 http://dx.doi.org/10.3390/ijms20081872 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Xiao-Yan
Ozawa, Shigeyuki
Kato, Yasumasa
Maehata, Yojiro
Izukuri, Kazuhito
Ikoma, Takeharu
Kanamori, Keisuke
Akasaka, Tetsu
Suzuki, Kenji
Iwabuchi, Hiroshi
Kurata, Shun-Ichi
Katoh, Iyoko
Sakurai, Takashi
Kiyono, Tohru
Hata, Ryu-Ichiro
C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression
title C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression
title_full C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression
title_fullStr C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression
title_full_unstemmed C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression
title_short C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression
title_sort c-x-c motif chemokine ligand 14 is a unique multifunctional regulator of tumor progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514660/
https://www.ncbi.nlm.nih.gov/pubmed/31014014
http://dx.doi.org/10.3390/ijms20081872
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