Cargando…

Flexicaulin A, An ent-Kaurane Diterpenoid, Activates p21 and Inhibits the Proliferation of Colorectal Carcinoma Cells through a Non-Apoptotic Mechanism

Natural products, explicitly medicinal plants, are an important source of inspiration of antitumor drugs, because they contain astounding amounts of small molecules that possess diversifying chemical entities. For instance, Isodon (formerly Rabdosia), a genus of the Lamiaceae (formerly Labiatae) fam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Yixuan, Lam, Chu Shing, Li, Wanfei, Sarwar, Md. Shahid, Liu, Kanglun, Lee, Kwan Ming, Zhang, Hong-Jie, Tsang, Siu Wai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514797/ https://www.ncbi.nlm.nih.gov/pubmed/31003485 http://dx.doi.org/10.3390/ijms20081917

Ejemplares similares

Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes
por: Sarwar, Md. Shahid, et al.
Publicado: (2020)

ent-Kaurane diterpenoids from the plant Wedelia trilobata
por: Ma, Bing-Ji, et al.
Publicado: (2013)

An ent-kaurane diterpenoid from Isodon japonica var. glaucocalyx
por: Bai, Su-Ping, et al.
Publicado: (2009)

Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound
por: Li, Dahong, et al.
Publicado: (2016)

Characterization of New Ent-kaurane Diterpenoids of Yunnan Arabica Coffee Beans
por: Chu, Rui, et al.
Publicado: (2016)

Anti-Neuroinflammatory ent-Kaurane Diterpenoids from Pteris multifida Roots
por: Kim, Jung Wha, et al.
Publicado: (2016)

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii
por: Zhan, Rui, et al.
Publicado: (2011)

A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation
por: Jiang, Shiyou, et al.
Publicado: (2015)

Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species
por: Yaouba, Souaibou, et al.
Publicado: (2018)

Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells
por: Hu, Yu, et al.
Publicado: (2018)

Bioactive Natural Spirolactone-Type 6,7-seco-ent-Kaurane Diterpenoids and Synthetic Derivatives
por: Li, Haonan, et al.
Publicado: (2018)

New ent-kaurane diterpenoid acids from Nouelia insignis Franch and their anti-inflammatory activity
por: Wu, Zhi-li, et al.
Publicado: (2022)

ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance
por: Sun, Yong, et al.
Publicado: (2021)

Ent-kaurane diterpenoids from the Annonaceae family: a review of research progress and call for further research
por: Ibrahim, Traore S., et al.
Publicado: (2023)

Synthesis of ent-Kaurane Diterpene Monoglycosides
por: Chaturvedula, Venkata Sai Prakash, et al.
Publicado: (2011)

Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids from Croton tonkinensis
por: Kuo, Ping-Chung, et al.
Publicado: (2020)

An ent-Kaurane-Type Diterpene in Croton antisyphiliticus Mart.
por: Pereira, Sarazete, et al.
Publicado: (2012)

Synthesis and Sensory Evaluation of ent-Kaurane Diterpene Glycosides
por: Prakash, Indra, et al.
Publicado: (2012)

Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells
por: Li, Xingyao, et al.
Publicado: (2013)

Fimbriatols A–J, Highly Oxidized ent-Kaurane Diterpenoids from Traditional Chinese Plant Flickingeria fimbriata (B1.) Hawkes
por: Ding, Gang, et al.
Publicado: (2016)

Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS
por: Hu, Jing, et al.
Publicado: (2019)

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity
por: Nogueira, Mauro S., et al.
Publicado: (2016)

New Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regelii
por: Fan, Dongsheng, et al.
Publicado: (2017)

A natural ent-kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion
por: Lee, Jin Sun, et al.
Publicado: (2018)

The Remarkable Structural Diversity Achieved in ent-Kaurane Diterpenes by Fungal Biotransformations
por: Takahashi, Jacqueline A., et al.
Publicado: (2014)

Three New Cytotoxic ent-Kaurane Diterpenes from Isodon excisoides
por: Dai, Li-Ping, et al.
Publicado: (2015)

Four New ent-Kaurane Diterpene Glycosides from Isodon henryi
por: Liu, Ya-Lin, et al.
Publicado: (2019)

New Ent-Kaurane-Type Diterpene Glycosides and Benzophenone from Ranunculus muricatus Linn.
por: Wu, Bi-Ling, et al.
Publicado: (2015)

Longikaurin A, a natural ent-kaurane, suppresses stemness in nasopharyngeal carcinoma cells
por: Yuan, Yan, et al.
Publicado: (2017)

One amino acid makes the difference: the formation of ent-kaurene and 16α-hydroxy-ent-kaurane by diterpene synthases in poplar
por: Irmisch, Sandra, et al.
Publicado: (2015)

Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi
por: Li, Wan-Fei, et al.
Publicado: (2015)

Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of ent-Kauranic Derivatives
por: Pruteanu, Elena, et al.
Publicado: (2021)

Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli
por: Li, Fang-Ru, et al.
Publicado: (2022)

Methoxylated Flavonols and ent-Kaurane Diterpenes from the South African Helichrysum rutilans and Their Cosmetic Potential
por: Popoola, Olugbenga K., et al.
Publicado: (2023)

Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species
por: Herrera-Acevedo, Chonny, et al.
Publicado: (2023)

Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia
por: Aimond, Axelle, et al.
Publicado: (2020)

Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis
por: Kalenga, Thobias M., et al.
Publicado: (2022)

Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities
por: Zhu, Qin-Feng, et al.
Publicado: (2022)

Bioactive Ent-Kaurane Diterpenes Oridonin and Irudonin Prevent Cancer Cells Migration by Interacting with the Actin Cytoskeleton Controller Ezrin
por: Pagliara, Valentina, et al.
Publicado: (2020)

Hydrogenation of the Exocyclic Olefinic Bond at C-16/C-17 Position of ent-Kaurane Diterpene Glycosides of Stevia rebaudiana Using Various Catalysts
por: Chaturvedula, Venkata Sai Prakash, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tvi9qqsm0und1ujrvb98hpddtb