Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products

Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were...

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Detalles Bibliográficos
Autores principales: Luo, Shangwen, Dong, Shi-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514808/
https://www.ncbi.nlm.nih.gov/pubmed/31003555
http://dx.doi.org/10.3390/molecules24081541
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author Luo, Shangwen
Dong, Shi-Hui
author_facet Luo, Shangwen
Dong, Shi-Hui
author_sort Luo, Shangwen
collection PubMed
description Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. This review article presents recent advances in the discovery of eukaryotic RiPP natural products, the elucidation of their biosynthetic pathways, and the molecular basis for their biosynthetic enzyme catalysis.
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spelling pubmed-65148082019-05-30 Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products Luo, Shangwen Dong, Shi-Hui Molecules Review Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. This review article presents recent advances in the discovery of eukaryotic RiPP natural products, the elucidation of their biosynthetic pathways, and the molecular basis for their biosynthetic enzyme catalysis. MDPI 2019-04-18 /pmc/articles/PMC6514808/ /pubmed/31003555 http://dx.doi.org/10.3390/molecules24081541 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Luo, Shangwen
Dong, Shi-Hui
Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products
title Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products
title_full Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products
title_fullStr Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products
title_full_unstemmed Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products
title_short Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products
title_sort recent advances in the discovery and biosynthetic study of eukaryotic ripp natural products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514808/
https://www.ncbi.nlm.nih.gov/pubmed/31003555
http://dx.doi.org/10.3390/molecules24081541
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AT dongshihui recentadvancesinthediscoveryandbiosyntheticstudyofeukaryoticrippnaturalproducts

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