A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we interrogated the AR-regulated proteome and identified PDZ binding kinase (PB...

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Detalles Bibliográficos
Autores principales: Warren, Anne Y., Massie, Charlie E., Watt, Kate, Luko, Katarina, Orafidiya, Folake, Selth, Luke A., Mohammed, Hisham, Chohan, Brinder S., Menon, Suraj, Baridi, Ajoeb, Zhao, Wanfeng, Escriu, Carles, Pungsrinont, Thanakorn, D’Santos, Clive, Yang, Xiaoping, Taylor, Chris, Qureshi, Arham, Zecchini, Vincent R., Shaw, Greg L., Dehm, Scott M., Mills, Ian G., Carroll, Jason S., Tilley, Wayne D., McEwan, Iain J., Baniahmad, Aria, Neal, David E., Asim, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514849/
https://www.ncbi.nlm.nih.gov/pubmed/30237440
http://dx.doi.org/10.1038/s41388-018-0501-z

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