Disruption of Structural Disulfides of Coagulation FXIII-B Subunit; Functional Implications for a Rare Bleeding Disorder

Congenital FXIII deficiency is a rare bleeding disorder in which mutations are detected in F13A1 and F13B genes that express the two subunits of coagulation FXIII, the catalytic FXIII-A, and protective FXIII-B. Mutations in FXIII-B subunit are considerably rarer compared to FXIII-A. Three mutations...

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Detalles Bibliográficos
Autores principales: Singh, Sneha, Akhter, Mohammad Suhail, Dodt, Johannes, Sharma, Amit, Kaniyappan, Senthilvelrajan, Yadegari, Hamideh, Ivaskevicius, Vytautas, Oldenburg, Johannes, Biswas, Arijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514982/
https://www.ncbi.nlm.nih.gov/pubmed/31013569
http://dx.doi.org/10.3390/ijms20081956

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