Discovery of Potent and Selective Halogen-Substituted Imidazole-Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro via Structure-Based Design

Employing a simple synthetic protocol, a series of highly effective halogen-substituted imidazole-thiosemicarbazides with anti-Toxoplasma gondii effects against the RH tachyzoites, much better than sulfadiazine, were obtained (IC(50s) 10.30—113.45 µg/mL vs. ~2721.45 µg/mL). The most potent of them,...

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Detalles Bibliográficos
Autores principales: Paneth, Agata, Węglińska, Lidia, Bekier, Adrian, Stefaniszyn, Edyta, Wujec, Monika, Trotsko, Nazar, Hawrył, Anna, Hawrył, Miroslaw, Dzitko, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514996/
https://www.ncbi.nlm.nih.gov/pubmed/31022878
http://dx.doi.org/10.3390/molecules24081618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514996/
https://www.ncbi.nlm.nih.gov/pubmed/31022878
http://dx.doi.org/10.3390/molecules24081618

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