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Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens
Cystic fibrosis (CF) is an autosomal recessive genetic disorder which leads to the secretion of a viscous mucus layer on the respiratory epithelium that facilitates colonization by various bacterial pathogens. The problem of drug resistance has been reported for all the species able to colonize the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515091/ https://www.ncbi.nlm.nih.gov/pubmed/31013936 http://dx.doi.org/10.3390/ijms20081838 |
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author | Scoffone, Viola Camilla Trespidi, Gabriele Chiarelli, Laurent R. Barbieri, Giulia Buroni, Silvia |
author_facet | Scoffone, Viola Camilla Trespidi, Gabriele Chiarelli, Laurent R. Barbieri, Giulia Buroni, Silvia |
author_sort | Scoffone, Viola Camilla |
collection | PubMed |
description | Cystic fibrosis (CF) is an autosomal recessive genetic disorder which leads to the secretion of a viscous mucus layer on the respiratory epithelium that facilitates colonization by various bacterial pathogens. The problem of drug resistance has been reported for all the species able to colonize the lung of CF patients, so alternative treatments are urgently needed. In this context, a valid approach is to investigate new natural and synthetic molecules for their ability to counteract alternative pathways, such as virulence regulating quorum sensing (QS). In this review we describe the pathogens most commonly associated with CF lung infections: Staphylococcus aureus, Pseudomonas aeruginosa, species of the Burkholderia cepacia complex and the emerging pathogens Stenotrophomonas maltophilia, Haemophilus influenzae and non-tuberculous Mycobacteria. For each bacterium, the QS system(s) and the molecules targeting the different components of this pathway are described. The amount of investigations published in the last five years clearly indicate the interest and the expectations on antivirulence therapy as an alternative to classical antibiotics. |
format | Online Article Text |
id | pubmed-6515091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65150912019-05-30 Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens Scoffone, Viola Camilla Trespidi, Gabriele Chiarelli, Laurent R. Barbieri, Giulia Buroni, Silvia Int J Mol Sci Review Cystic fibrosis (CF) is an autosomal recessive genetic disorder which leads to the secretion of a viscous mucus layer on the respiratory epithelium that facilitates colonization by various bacterial pathogens. The problem of drug resistance has been reported for all the species able to colonize the lung of CF patients, so alternative treatments are urgently needed. In this context, a valid approach is to investigate new natural and synthetic molecules for their ability to counteract alternative pathways, such as virulence regulating quorum sensing (QS). In this review we describe the pathogens most commonly associated with CF lung infections: Staphylococcus aureus, Pseudomonas aeruginosa, species of the Burkholderia cepacia complex and the emerging pathogens Stenotrophomonas maltophilia, Haemophilus influenzae and non-tuberculous Mycobacteria. For each bacterium, the QS system(s) and the molecules targeting the different components of this pathway are described. The amount of investigations published in the last five years clearly indicate the interest and the expectations on antivirulence therapy as an alternative to classical antibiotics. MDPI 2019-04-13 /pmc/articles/PMC6515091/ /pubmed/31013936 http://dx.doi.org/10.3390/ijms20081838 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Scoffone, Viola Camilla Trespidi, Gabriele Chiarelli, Laurent R. Barbieri, Giulia Buroni, Silvia Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens |
title | Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens |
title_full | Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens |
title_fullStr | Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens |
title_full_unstemmed | Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens |
title_short | Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens |
title_sort | quorum sensing as antivirulence target in cystic fibrosis pathogens |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515091/ https://www.ncbi.nlm.nih.gov/pubmed/31013936 http://dx.doi.org/10.3390/ijms20081838 |
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