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Second-Generation Histamine H1 Receptor Antagonists Suppress Delayed Rectifier K(+)-Channel Currents in Murine Thymocytes

BACKGROUND/AIMS: Voltage-dependent potassium channels (Kv1.3) are predominantly expressed in lymphocyte plasma membranes. These channels are critical for the activation and proliferation of lymphocytes. Since second-generation antihistamines are lipophilic and exert immunomodulatory effects, they ar...

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Detalles Bibliográficos
Autores principales:	Saito, Kazutomo, Abe, Nozomu, Toyama, Hiroaki, Ejima, Yutaka, Yamauchi, Masanori, Mushiake, Hajime, Kazama, Itsuro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515180/ https://www.ncbi.nlm.nih.gov/pubmed/31183371 http://dx.doi.org/10.1155/2019/6261951

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