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Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing

Propolis is the generic name of a complex of resinous compound collected by honeybees and it has been utilized for many years in folk medicine. As other products generated by honeybees (such as royal jelly, pollen, honey), propolis has great therapeutic properties, but very little scientific informa...

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Detalles Bibliográficos
Autores principales: Martinotti, Simona, Pellavio, Giorgia, Laforenza, Umberto, Ranzato, Elia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515181/
https://www.ncbi.nlm.nih.gov/pubmed/31010117
http://dx.doi.org/10.3390/molecules24081544
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author Martinotti, Simona
Pellavio, Giorgia
Laforenza, Umberto
Ranzato, Elia
author_facet Martinotti, Simona
Pellavio, Giorgia
Laforenza, Umberto
Ranzato, Elia
author_sort Martinotti, Simona
collection PubMed
description Propolis is the generic name of a complex of resinous compound collected by honeybees and it has been utilized for many years in folk medicine. As other products generated by honeybees (such as royal jelly, pollen, honey), propolis has great therapeutic properties, but very little scientific information is available. Therefore, this study was aimed at exploring the potential wound healing properties of propolis. To that end, we utilized an in vitro scratch wound healing model consisting of human immortalized keratinocytes. Our scratch wound data clearly demonstrated that propolis induced a pronounced increase in the wound repair abilities of keratinocytes. A cell migration assay showed that propolis stimulated keratinocytes to close the wound. We revealed the role of H(2)O(2) as the main mediator of propolis regenerative properties. We showed that this extracellularly released H(2)O(2) could pass across the plasma membrane through a specific aquaporin (i.e., AQP3) modulating intracellular responses. The data offer a biological characterization of propolis positive effects suggesting that propolis could also be utilized in wound treatment within clinical settings.
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spelling pubmed-65151812019-05-30 Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing Martinotti, Simona Pellavio, Giorgia Laforenza, Umberto Ranzato, Elia Molecules Article Propolis is the generic name of a complex of resinous compound collected by honeybees and it has been utilized for many years in folk medicine. As other products generated by honeybees (such as royal jelly, pollen, honey), propolis has great therapeutic properties, but very little scientific information is available. Therefore, this study was aimed at exploring the potential wound healing properties of propolis. To that end, we utilized an in vitro scratch wound healing model consisting of human immortalized keratinocytes. Our scratch wound data clearly demonstrated that propolis induced a pronounced increase in the wound repair abilities of keratinocytes. A cell migration assay showed that propolis stimulated keratinocytes to close the wound. We revealed the role of H(2)O(2) as the main mediator of propolis regenerative properties. We showed that this extracellularly released H(2)O(2) could pass across the plasma membrane through a specific aquaporin (i.e., AQP3) modulating intracellular responses. The data offer a biological characterization of propolis positive effects suggesting that propolis could also be utilized in wound treatment within clinical settings. MDPI 2019-04-19 /pmc/articles/PMC6515181/ /pubmed/31010117 http://dx.doi.org/10.3390/molecules24081544 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martinotti, Simona
Pellavio, Giorgia
Laforenza, Umberto
Ranzato, Elia
Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing
title Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing
title_full Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing
title_fullStr Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing
title_full_unstemmed Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing
title_short Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing
title_sort propolis induces aqp3 expression: a possible way of action in wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515181/
https://www.ncbi.nlm.nih.gov/pubmed/31010117
http://dx.doi.org/10.3390/molecules24081544
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