Cargando…
Fabrication and Applications of Solid-State Nanopores
Nanopores fabricated from synthetic materials (solid-state nanopores), platforms for characterizing biological molecules, have been widely studied among researchers. Compared with biological nanopores, solid-state nanopores are mechanically robust and durable with a tunable pore size and geometry. S...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515193/ https://www.ncbi.nlm.nih.gov/pubmed/31010038 http://dx.doi.org/10.3390/s19081886 |
_version_ | 1783418034971475968 |
---|---|
author | Chen, Qi Liu, Zewen |
author_facet | Chen, Qi Liu, Zewen |
author_sort | Chen, Qi |
collection | PubMed |
description | Nanopores fabricated from synthetic materials (solid-state nanopores), platforms for characterizing biological molecules, have been widely studied among researchers. Compared with biological nanopores, solid-state nanopores are mechanically robust and durable with a tunable pore size and geometry. Solid-state nanopores with sizes as small as 1.3 nm have been fabricated in various films using engraving techniques, such as focused ion beam (FIB) and focused electron beam (FEB) drilling methods. With the demand of massively parallel sensing, many scalable fabrication strategies have been proposed. In this review, typical fabrication technologies for solid-state nanopores reported to date are summarized, with the advantages and limitations of each technology discussed in detail. Advanced shrinking strategies to prepare nanopores with desired shapes and sizes down to sub-1 nm are concluded. Finally, applications of solid-state nanopores in DNA sequencing, single molecule detection, ion-selective transport, and nanopatterning are outlined. |
format | Online Article Text |
id | pubmed-6515193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65151932019-05-30 Fabrication and Applications of Solid-State Nanopores Chen, Qi Liu, Zewen Sensors (Basel) Review Nanopores fabricated from synthetic materials (solid-state nanopores), platforms for characterizing biological molecules, have been widely studied among researchers. Compared with biological nanopores, solid-state nanopores are mechanically robust and durable with a tunable pore size and geometry. Solid-state nanopores with sizes as small as 1.3 nm have been fabricated in various films using engraving techniques, such as focused ion beam (FIB) and focused electron beam (FEB) drilling methods. With the demand of massively parallel sensing, many scalable fabrication strategies have been proposed. In this review, typical fabrication technologies for solid-state nanopores reported to date are summarized, with the advantages and limitations of each technology discussed in detail. Advanced shrinking strategies to prepare nanopores with desired shapes and sizes down to sub-1 nm are concluded. Finally, applications of solid-state nanopores in DNA sequencing, single molecule detection, ion-selective transport, and nanopatterning are outlined. MDPI 2019-04-20 /pmc/articles/PMC6515193/ /pubmed/31010038 http://dx.doi.org/10.3390/s19081886 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Qi Liu, Zewen Fabrication and Applications of Solid-State Nanopores |
title | Fabrication and Applications of Solid-State Nanopores |
title_full | Fabrication and Applications of Solid-State Nanopores |
title_fullStr | Fabrication and Applications of Solid-State Nanopores |
title_full_unstemmed | Fabrication and Applications of Solid-State Nanopores |
title_short | Fabrication and Applications of Solid-State Nanopores |
title_sort | fabrication and applications of solid-state nanopores |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515193/ https://www.ncbi.nlm.nih.gov/pubmed/31010038 http://dx.doi.org/10.3390/s19081886 |
work_keys_str_mv | AT chenqi fabricationandapplicationsofsolidstatenanopores AT liuzewen fabricationandapplicationsofsolidstatenanopores |