Coumarins and P450s, Studies Reported to-Date

Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species. In addition to their role in detoxification, they play important roles in the biosyn...

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Autores principales: Foroozesh, Maryam, Sridhar, Jayalakshmi, Goyal, Navneet, Liu, Jiawang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515222/
https://www.ncbi.nlm.nih.gov/pubmed/31022888
http://dx.doi.org/10.3390/molecules24081620
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author Foroozesh, Maryam
Sridhar, Jayalakshmi
Goyal, Navneet
Liu, Jiawang
author_facet Foroozesh, Maryam
Sridhar, Jayalakshmi
Goyal, Navneet
Liu, Jiawang
author_sort Foroozesh, Maryam
collection PubMed
description Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species. In addition to their role in detoxification, they play important roles in the biosynthesis of endogenous compounds and the bioactivation of xenobiotics. Coumarins, phytochemicals abundant in food and commonly used in fragrances and cosmetics, have been shown to interact with P450 enzymes as substrates and/or inhibitors. In this review, these interactions and their significance in pharmacology and toxicology are discussed in detail.
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spelling pubmed-65152222019-05-30 Coumarins and P450s, Studies Reported to-Date Foroozesh, Maryam Sridhar, Jayalakshmi Goyal, Navneet Liu, Jiawang Molecules Review Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species. In addition to their role in detoxification, they play important roles in the biosynthesis of endogenous compounds and the bioactivation of xenobiotics. Coumarins, phytochemicals abundant in food and commonly used in fragrances and cosmetics, have been shown to interact with P450 enzymes as substrates and/or inhibitors. In this review, these interactions and their significance in pharmacology and toxicology are discussed in detail. MDPI 2019-04-24 /pmc/articles/PMC6515222/ /pubmed/31022888 http://dx.doi.org/10.3390/molecules24081620 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Foroozesh, Maryam
Sridhar, Jayalakshmi
Goyal, Navneet
Liu, Jiawang
Coumarins and P450s, Studies Reported to-Date
title Coumarins and P450s, Studies Reported to-Date
title_full Coumarins and P450s, Studies Reported to-Date
title_fullStr Coumarins and P450s, Studies Reported to-Date
title_full_unstemmed Coumarins and P450s, Studies Reported to-Date
title_short Coumarins and P450s, Studies Reported to-Date
title_sort coumarins and p450s, studies reported to-date
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515222/
https://www.ncbi.nlm.nih.gov/pubmed/31022888
http://dx.doi.org/10.3390/molecules24081620
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AT liujiawang coumarinsandp450sstudiesreportedtodate

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