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The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection

The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite...

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Autores principales: Clain, Elodie, Haddad, Juliano G., Koishi, Andrea C., Sinigaglia, Laura, Rachidi, Walid, Desprès, Philippe, N. Duarte dos Santos, Claudia, Guiraud, Pascale, Jouvenet, Nolwenn, El Kalamouni, Chaker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515236/
https://www.ncbi.nlm.nih.gov/pubmed/30991717
http://dx.doi.org/10.3390/ijms20081860
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author Clain, Elodie
Haddad, Juliano G.
Koishi, Andrea C.
Sinigaglia, Laura
Rachidi, Walid
Desprès, Philippe
N. Duarte dos Santos, Claudia
Guiraud, Pascale
Jouvenet, Nolwenn
El Kalamouni, Chaker
author_facet Clain, Elodie
Haddad, Juliano G.
Koishi, Andrea C.
Sinigaglia, Laura
Rachidi, Walid
Desprès, Philippe
N. Duarte dos Santos, Claudia
Guiraud, Pascale
Jouvenet, Nolwenn
El Kalamouni, Chaker
author_sort Clain, Elodie
collection PubMed
description The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the P. mauritianum extract interfered with the attachment of the viral particles to the host cells. Importantly, the P. mauritianum extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, P. mauritianum may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses.
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spelling pubmed-65152362019-05-30 The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection Clain, Elodie Haddad, Juliano G. Koishi, Andrea C. Sinigaglia, Laura Rachidi, Walid Desprès, Philippe N. Duarte dos Santos, Claudia Guiraud, Pascale Jouvenet, Nolwenn El Kalamouni, Chaker Int J Mol Sci Article The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the P. mauritianum extract interfered with the attachment of the viral particles to the host cells. Importantly, the P. mauritianum extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, P. mauritianum may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses. MDPI 2019-04-15 /pmc/articles/PMC6515236/ /pubmed/30991717 http://dx.doi.org/10.3390/ijms20081860 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Clain, Elodie
Haddad, Juliano G.
Koishi, Andrea C.
Sinigaglia, Laura
Rachidi, Walid
Desprès, Philippe
N. Duarte dos Santos, Claudia
Guiraud, Pascale
Jouvenet, Nolwenn
El Kalamouni, Chaker
The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection
title The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection
title_full The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection
title_fullStr The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection
title_full_unstemmed The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection
title_short The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection
title_sort polyphenol-rich extract from psiloxylon mauritianum, an endemic medicinal plant from reunion island, inhibits the early stages of dengue and zika virus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515236/
https://www.ncbi.nlm.nih.gov/pubmed/30991717
http://dx.doi.org/10.3390/ijms20081860
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