Cargando…

The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic mar...

Descripción completa

Detalles Bibliográficos
Autores principales: Gensous, Noémie, Franceschi, Claudio, Santoro, Aurelia, Milazzo, Maddalena, Garagnani, Paolo, Bacalini, Maria Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515465/
https://www.ncbi.nlm.nih.gov/pubmed/31022953
http://dx.doi.org/10.3390/ijms20082022
Descripción
Sumario:Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic marks associated with aging. In this review, we will assess the current advances in the relationship between caloric restriction, a proven anti-aging intervention, and epigenetic signatures of aging. We will specifically discuss the impact of caloric restriction on epigenetic regulation and how some of the favorable effects of caloric restriction on lifespan and healthspan could be mediated by epigenetic modifications.