The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic mar...

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Autores principales: Gensous, Noémie, Franceschi, Claudio, Santoro, Aurelia, Milazzo, Maddalena, Garagnani, Paolo, Bacalini, Maria Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515465/
https://www.ncbi.nlm.nih.gov/pubmed/31022953
http://dx.doi.org/10.3390/ijms20082022
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author Gensous, Noémie
Franceschi, Claudio
Santoro, Aurelia
Milazzo, Maddalena
Garagnani, Paolo
Bacalini, Maria Giulia
author_facet Gensous, Noémie
Franceschi, Claudio
Santoro, Aurelia
Milazzo, Maddalena
Garagnani, Paolo
Bacalini, Maria Giulia
author_sort Gensous, Noémie
collection PubMed
description Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic marks associated with aging. In this review, we will assess the current advances in the relationship between caloric restriction, a proven anti-aging intervention, and epigenetic signatures of aging. We will specifically discuss the impact of caloric restriction on epigenetic regulation and how some of the favorable effects of caloric restriction on lifespan and healthspan could be mediated by epigenetic modifications.
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spelling pubmed-65154652019-05-30 The Impact of Caloric Restriction on the Epigenetic Signatures of Aging Gensous, Noémie Franceschi, Claudio Santoro, Aurelia Milazzo, Maddalena Garagnani, Paolo Bacalini, Maria Giulia Int J Mol Sci Review Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic marks associated with aging. In this review, we will assess the current advances in the relationship between caloric restriction, a proven anti-aging intervention, and epigenetic signatures of aging. We will specifically discuss the impact of caloric restriction on epigenetic regulation and how some of the favorable effects of caloric restriction on lifespan and healthspan could be mediated by epigenetic modifications. MDPI 2019-04-24 /pmc/articles/PMC6515465/ /pubmed/31022953 http://dx.doi.org/10.3390/ijms20082022 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gensous, Noémie
Franceschi, Claudio
Santoro, Aurelia
Milazzo, Maddalena
Garagnani, Paolo
Bacalini, Maria Giulia
The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
title The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
title_full The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
title_fullStr The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
title_full_unstemmed The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
title_short The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
title_sort impact of caloric restriction on the epigenetic signatures of aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515465/
https://www.ncbi.nlm.nih.gov/pubmed/31022953
http://dx.doi.org/10.3390/ijms20082022
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