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Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora

Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (5−7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffrac...

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Detalles Bibliográficos
Autores principales: Zhu, Chuan-Zhi, Hu, Bin-Yuan, Liu, Jia-Wang, Cai, Yi, Chen, Xin-Chun, Qin, Da-Peng, Cheng, Yong-Xian, Zhang, Zong-De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515556/
https://www.ncbi.nlm.nih.gov/pubmed/30991677
http://dx.doi.org/10.3390/molecules24081475
Descripción
Sumario:Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (5−7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels–Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined.