ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

BACKGROUND: Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cerebral vessels known as cerebral amyloid angiopathy (CAA), microhemorrhages, and v...

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Detalles Bibliográficos
Autores principales: Button, Emily B., Boyce, Guilaine K., Wilkinson, Anna, Stukas, Sophie, Hayat, Arooj, Fan, Jianjia, Wadsworth, Brennan J., Robert, Jerome, Martens, Kris M., Wellington, Cheryl L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515644/
https://www.ncbi.nlm.nih.gov/pubmed/31084613
http://dx.doi.org/10.1186/s13195-019-0497-9

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