VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

BACKGROUND: VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data. We apply our method to dissect the regulation of estrogen receptor-alpha activati...

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Detalles Bibliográficos
Autores principales: Holding, Andrew N., Giorgi, Federico M., Donnelly, Amanda, Cullen, Amy E., Nagarajan, Sankari, Selth, Luke A., Markowetz, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515683/
https://www.ncbi.nlm.nih.gov/pubmed/31084623
http://dx.doi.org/10.1186/s13059-019-1698-z

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