The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors

Fraxetin, a natural compound present in many dietary supplements and herbs, is useful in the treatment of acute bacillary dysentery and type 2 diabetes. Previously, several metabolic studies have revealed extensive first-pass metabolism causing formation of fraxetin-O-glucuronides (G1 and G2), resul...

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Detalles Bibliográficos
Autores principales: Qin, Zifei, Zhang, Beibei, Yang, Jing, Li, Shishi, Xu, Jinjin, Yao, Zhihong, Zhang, Xiaojian, Gonzalez, Frank J., Yao, Xinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515931/
https://www.ncbi.nlm.nih.gov/pubmed/31133859
http://dx.doi.org/10.3389/fphar.2019.00496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515931/
https://www.ncbi.nlm.nih.gov/pubmed/31133859
http://dx.doi.org/10.3389/fphar.2019.00496

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