mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

Aging leads to skeletal muscle atrophy (i.e., sarcopenia), and muscle fiber loss is a critical component of this process. The mechanisms underlying these age‐related changes, however, remain unclear. We show here that mTORC1 signaling is activated in a subset of skeletal muscle fibers in aging mouse...

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Detalles Bibliográficos
Autores principales: Tang, Huibin, Inoki, Ken, Brooks, Susan V., Okazawa, Hideki, Lee, Myung, Wang, Junying, Kim, Michael, Kennedy, Catherine L., Macpherson, Peter C. D., Ji, Xuhuai, Van Roekel, Sabrina, Fraga, Danielle A., Wang, Kun, Zhu, Jinguo, Wang, Yoyo, Sharp, Zelton D., Miller, Richard A., Rando, Thomas A., Goldman, Daniel, Guan, Kun‐Liang, Shrager, Joseph B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516169/
https://www.ncbi.nlm.nih.gov/pubmed/30924297
http://dx.doi.org/10.1111/acel.12943

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