PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

Brain lesions in Alzheimer's disease (AD) include amyloid plaques made of Aβ peptides and neurofibrillary tangles composed of hyperphosphorylated tau protein with synaptic and neuronal loss and neuroinflammation. Aβ oligomers can trigger tau phosphorylation and neuronal alterations through acti...

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Detalles Bibliográficos
Autores principales: Tible, Marion, Mouton Liger, François, Schmitt, Julien, Giralt, Albert, Farid, Karim, Thomasseau, Sylvie, Gourmaud, Sarah, Paquet, Claire, Rondi Reig, Laure, Meurs, Eliane, Girault, Jean‐Antoine, Hugon, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516179/
https://www.ncbi.nlm.nih.gov/pubmed/30821420
http://dx.doi.org/10.1111/acel.12887

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