Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the...

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Autores principales: Palmer, Allyson K., Xu, Ming, Zhu, Yi, Pirtskhalava, Tamar, Weivoda, Megan M., Hachfeld, Christine M., Prata, Larissa G., van Dijk, Theo H., Verkade, Esther, Casaclang‐Verzosa, Grace, Johnson, Kurt O., Cubro, Hajrunisa, Doornebal, Ewald J., Ogrodnik, Mikolaj, Jurk, Diana, Jensen, Michael D., Chini, Eduardo N., Miller, Jordan D., Matveyenko, Aleksey, Stout, Michael B., Schafer, Marissa J., White, Thomas A., Hickson, LaTonya J., Demaria, Marco, Garovic, Vesna, Grande, Joseph, Arriaga, Edgar A., Kuipers, Folkert, von Zglinicki, Thomas, LeBrasseur, Nathan K., Campisi, Judith, Tchkonia, Tamar, Kirkland, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516193/
https://www.ncbi.nlm.nih.gov/pubmed/30907060
http://dx.doi.org/10.1111/acel.12950

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