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A degradation fragment of type X collagen is a real-time marker for bone growth velocity

Despite its importance as a key parameter of child health and development, growth velocity is difficult to determine in real timebecause skeletal growth is slowand clinical tools to accurately detect very small increments of growth do not exist. We report discovery of a marker for skeletal growth in...

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Autores principales: Coghlan, Ryan F., Oberdorf, Jon A., Sienko, Susan, Aiona, Michael D., Boston, Bruce A., Connelly, Kara J., Bahney, Chelsea, LaRouche, Jeremie, Almubarak, Sarah M., Coleman, Daniel T., Girkontaite, Irute, von der Mark, Klaus, Lunstrum, Gregory P., Horton, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516194/
https://www.ncbi.nlm.nih.gov/pubmed/29212713
http://dx.doi.org/10.1126/scitranslmed.aan4669
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author Coghlan, Ryan F.
Oberdorf, Jon A.
Sienko, Susan
Aiona, Michael D.
Boston, Bruce A.
Connelly, Kara J.
Bahney, Chelsea
LaRouche, Jeremie
Almubarak, Sarah M.
Coleman, Daniel T.
Girkontaite, Irute
von der Mark, Klaus
Lunstrum, Gregory P.
Horton, William A.
author_facet Coghlan, Ryan F.
Oberdorf, Jon A.
Sienko, Susan
Aiona, Michael D.
Boston, Bruce A.
Connelly, Kara J.
Bahney, Chelsea
LaRouche, Jeremie
Almubarak, Sarah M.
Coleman, Daniel T.
Girkontaite, Irute
von der Mark, Klaus
Lunstrum, Gregory P.
Horton, William A.
author_sort Coghlan, Ryan F.
collection PubMed
description Despite its importance as a key parameter of child health and development, growth velocity is difficult to determine in real timebecause skeletal growth is slowand clinical tools to accurately detect very small increments of growth do not exist. We report discovery of a marker for skeletal growth in infants and children. The intact trimeric noncollagenous 1 (NC1) domain of type X collagen, the markerwe designated as CXMfor Collagen X Marker, is a degradation by-product of endochondral ossification that is released into the circulation in proportion to overall growth plate activity. Thismarker corresponds to the rate of linear bone growth at timeofmeasurement. Serumconcentrations of CXMplotted against age showa pattern similar to well-established height growth velocity curves and correlate with height growth velocity calculated from incremental height measurements in this study. The CXM marker is stable once collected and can be accurately assayed in serum, plasma, and dried blood spots. CXMtestingmay be useful for monitoring growth in the pediatric population, especially responses of infants and children with genetic and acquired growth disorders to interventions that target the underlying growth disturbances. The utility of CXM may potentially extend to managing other conditions such as fracture healing, scoliosis, arthritis, or cancer.
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spelling pubmed-65161942019-05-30 A degradation fragment of type X collagen is a real-time marker for bone growth velocity Coghlan, Ryan F. Oberdorf, Jon A. Sienko, Susan Aiona, Michael D. Boston, Bruce A. Connelly, Kara J. Bahney, Chelsea LaRouche, Jeremie Almubarak, Sarah M. Coleman, Daniel T. Girkontaite, Irute von der Mark, Klaus Lunstrum, Gregory P. Horton, William A. Sci Transl Med Bone Despite its importance as a key parameter of child health and development, growth velocity is difficult to determine in real timebecause skeletal growth is slowand clinical tools to accurately detect very small increments of growth do not exist. We report discovery of a marker for skeletal growth in infants and children. The intact trimeric noncollagenous 1 (NC1) domain of type X collagen, the markerwe designated as CXMfor Collagen X Marker, is a degradation by-product of endochondral ossification that is released into the circulation in proportion to overall growth plate activity. Thismarker corresponds to the rate of linear bone growth at timeofmeasurement. Serumconcentrations of CXMplotted against age showa pattern similar to well-established height growth velocity curves and correlate with height growth velocity calculated from incremental height measurements in this study. The CXM marker is stable once collected and can be accurately assayed in serum, plasma, and dried blood spots. CXMtestingmay be useful for monitoring growth in the pediatric population, especially responses of infants and children with genetic and acquired growth disorders to interventions that target the underlying growth disturbances. The utility of CXM may potentially extend to managing other conditions such as fracture healing, scoliosis, arthritis, or cancer. American Association for the Advancement of Science 2017-12-06 2017 /pmc/articles/PMC6516194/ /pubmed/29212713 http://dx.doi.org/10.1126/scitranslmed.aan4669 Text en © 2017 The Authors, some rights reserved https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Bone
Coghlan, Ryan F.
Oberdorf, Jon A.
Sienko, Susan
Aiona, Michael D.
Boston, Bruce A.
Connelly, Kara J.
Bahney, Chelsea
LaRouche, Jeremie
Almubarak, Sarah M.
Coleman, Daniel T.
Girkontaite, Irute
von der Mark, Klaus
Lunstrum, Gregory P.
Horton, William A.
A degradation fragment of type X collagen is a real-time marker for bone growth velocity
title A degradation fragment of type X collagen is a real-time marker for bone growth velocity
title_full A degradation fragment of type X collagen is a real-time marker for bone growth velocity
title_fullStr A degradation fragment of type X collagen is a real-time marker for bone growth velocity
title_full_unstemmed A degradation fragment of type X collagen is a real-time marker for bone growth velocity
title_short A degradation fragment of type X collagen is a real-time marker for bone growth velocity
title_sort degradation fragment of type x collagen is a real-time marker for bone growth velocity
topic Bone
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516194/
https://www.ncbi.nlm.nih.gov/pubmed/29212713
http://dx.doi.org/10.1126/scitranslmed.aan4669
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