Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that drives growth and suppresses activity of the MiT/T...

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Detalles Bibliográficos
Autores principales: Murphy, John T., Liu, Haiyan, Ma, Xiucui, Shaver, Alex, Egan, Brian M., Oh, Clara, Boyko, Alexander, Mazer, Travis, Ang, Samuel, Khopkar, Rohan, Javaheri, Ali, Kumar, Sandeep, Jiang, Xuntian, Ory, Daniel, Mani, Kartik, Matkovich, Scot J., Kornfeld, Kerry, Diwan, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516633/
https://www.ncbi.nlm.nih.gov/pubmed/31086360
http://dx.doi.org/10.1371/journal.pbio.3000245

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