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Astrocyte senescence: Evidence and significance
Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been pro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516680/ https://www.ncbi.nlm.nih.gov/pubmed/30815970 http://dx.doi.org/10.1111/acel.12937 |
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author | Cohen, Justin Torres, Claudio |
author_facet | Cohen, Justin Torres, Claudio |
author_sort | Cohen, Justin |
collection | PubMed |
description | Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central component of the age dependency of neurodegenerative disorders. Cumulative evidence supports an integral role of astrocytes in the initiation and progression of neurodegenerative disease and cognitive decline with aging. The loss of astrocyte function or the gain of neuroinflammatory function as a result of cellular senescence could have profound implications for the aging brain and neurodegenerative disorders, and we propose the term “astrosenescence” to describe this phenotype. This review summarizes the current evidence pertaining to astrocyte senescence from early evidence, in vitro characterization and relationship to age‐related neurodegenerative disease. We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease. |
format | Online Article Text |
id | pubmed-6516680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65166802019-06-01 Astrocyte senescence: Evidence and significance Cohen, Justin Torres, Claudio Aging Cell Reviews Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central component of the age dependency of neurodegenerative disorders. Cumulative evidence supports an integral role of astrocytes in the initiation and progression of neurodegenerative disease and cognitive decline with aging. The loss of astrocyte function or the gain of neuroinflammatory function as a result of cellular senescence could have profound implications for the aging brain and neurodegenerative disorders, and we propose the term “astrosenescence” to describe this phenotype. This review summarizes the current evidence pertaining to astrocyte senescence from early evidence, in vitro characterization and relationship to age‐related neurodegenerative disease. We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease. John Wiley and Sons Inc. 2019-02-27 2019-06 /pmc/articles/PMC6516680/ /pubmed/30815970 http://dx.doi.org/10.1111/acel.12937 Text en © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Cohen, Justin Torres, Claudio Astrocyte senescence: Evidence and significance |
title | Astrocyte senescence: Evidence and significance |
title_full | Astrocyte senescence: Evidence and significance |
title_fullStr | Astrocyte senescence: Evidence and significance |
title_full_unstemmed | Astrocyte senescence: Evidence and significance |
title_short | Astrocyte senescence: Evidence and significance |
title_sort | astrocyte senescence: evidence and significance |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516680/ https://www.ncbi.nlm.nih.gov/pubmed/30815970 http://dx.doi.org/10.1111/acel.12937 |
work_keys_str_mv | AT cohenjustin astrocytesenescenceevidenceandsignificance AT torresclaudio astrocytesenescenceevidenceandsignificance |