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Astrocyte senescence: Evidence and significance

Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been pro...

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Detalles Bibliográficos
Autores principales: Cohen, Justin, Torres, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516680/
https://www.ncbi.nlm.nih.gov/pubmed/30815970
http://dx.doi.org/10.1111/acel.12937
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author Cohen, Justin
Torres, Claudio
author_facet Cohen, Justin
Torres, Claudio
author_sort Cohen, Justin
collection PubMed
description Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central component of the age dependency of neurodegenerative disorders. Cumulative evidence supports an integral role of astrocytes in the initiation and progression of neurodegenerative disease and cognitive decline with aging. The loss of astrocyte function or the gain of neuroinflammatory function as a result of cellular senescence could have profound implications for the aging brain and neurodegenerative disorders, and we propose the term “astrosenescence” to describe this phenotype. This review summarizes the current evidence pertaining to astrocyte senescence from early evidence, in vitro characterization and relationship to age‐related neurodegenerative disease. We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease.
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spelling pubmed-65166802019-06-01 Astrocyte senescence: Evidence and significance Cohen, Justin Torres, Claudio Aging Cell Reviews Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central component of the age dependency of neurodegenerative disorders. Cumulative evidence supports an integral role of astrocytes in the initiation and progression of neurodegenerative disease and cognitive decline with aging. The loss of astrocyte function or the gain of neuroinflammatory function as a result of cellular senescence could have profound implications for the aging brain and neurodegenerative disorders, and we propose the term “astrosenescence” to describe this phenotype. This review summarizes the current evidence pertaining to astrocyte senescence from early evidence, in vitro characterization and relationship to age‐related neurodegenerative disease. We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease. John Wiley and Sons Inc. 2019-02-27 2019-06 /pmc/articles/PMC6516680/ /pubmed/30815970 http://dx.doi.org/10.1111/acel.12937 Text en © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Cohen, Justin
Torres, Claudio
Astrocyte senescence: Evidence and significance
title Astrocyte senescence: Evidence and significance
title_full Astrocyte senescence: Evidence and significance
title_fullStr Astrocyte senescence: Evidence and significance
title_full_unstemmed Astrocyte senescence: Evidence and significance
title_short Astrocyte senescence: Evidence and significance
title_sort astrocyte senescence: evidence and significance
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516680/
https://www.ncbi.nlm.nih.gov/pubmed/30815970
http://dx.doi.org/10.1111/acel.12937
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