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Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway
Early adverse experiences often have devastating consequences. However, whether preweaning paternal deprivation (PD) affects emotional and social behaviors and their underlying neural mechanisms remain unexplored. Using monogamous mandarin voles, we found that PD increased anxiety-like behavior and...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516825/ https://www.ncbi.nlm.nih.gov/pubmed/31084703 http://dx.doi.org/10.7554/eLife.44026 |
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author | He, Zhixiong Young, Larry Ma, Xin-Ming Guo, Qianqian Wang, Limin Yang, Yang Luo, Luo Yuan, Wei Li, Laifu Zhang, Jing Hou, Wenjuan Qiao, Hui Jia, Rui Tai, Fadao |
author_facet | He, Zhixiong Young, Larry Ma, Xin-Ming Guo, Qianqian Wang, Limin Yang, Yang Luo, Luo Yuan, Wei Li, Laifu Zhang, Jing Hou, Wenjuan Qiao, Hui Jia, Rui Tai, Fadao |
author_sort | He, Zhixiong |
collection | PubMed |
description | Early adverse experiences often have devastating consequences. However, whether preweaning paternal deprivation (PD) affects emotional and social behaviors and their underlying neural mechanisms remain unexplored. Using monogamous mandarin voles, we found that PD increased anxiety-like behavior and attenuated social preference in adulthood. PD also decreased the number of oxytocin (OT)-positive neurons projecting from the paraventricular nucleus (PVN) and reduced the levels of the medial prefrontal cortex OT receptor protein in females and of the OT receptor and V1a receptor proteins in males. Intra-prelimbic cortical OT injections reversed the PD-induced changes in anxiety-like behavior and social preferences. Optogenetic activation of the prelimbic cortex OT terminals from PVN OT neurons reversed the PD-induced changes in emotion and social preference behaviors, whereas optogenetic inhibition was anxiogenic and impaired social preference in naive voles. These findings demonstrate that PD increases anxiety-like behavior and attenuates social preferences through the involvement of PVN OT neuron projections to the prelimbic cortex. |
format | Online Article Text |
id | pubmed-6516825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65168252019-05-16 Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway He, Zhixiong Young, Larry Ma, Xin-Ming Guo, Qianqian Wang, Limin Yang, Yang Luo, Luo Yuan, Wei Li, Laifu Zhang, Jing Hou, Wenjuan Qiao, Hui Jia, Rui Tai, Fadao eLife Neuroscience Early adverse experiences often have devastating consequences. However, whether preweaning paternal deprivation (PD) affects emotional and social behaviors and their underlying neural mechanisms remain unexplored. Using monogamous mandarin voles, we found that PD increased anxiety-like behavior and attenuated social preference in adulthood. PD also decreased the number of oxytocin (OT)-positive neurons projecting from the paraventricular nucleus (PVN) and reduced the levels of the medial prefrontal cortex OT receptor protein in females and of the OT receptor and V1a receptor proteins in males. Intra-prelimbic cortical OT injections reversed the PD-induced changes in anxiety-like behavior and social preferences. Optogenetic activation of the prelimbic cortex OT terminals from PVN OT neurons reversed the PD-induced changes in emotion and social preference behaviors, whereas optogenetic inhibition was anxiogenic and impaired social preference in naive voles. These findings demonstrate that PD increases anxiety-like behavior and attenuates social preferences through the involvement of PVN OT neuron projections to the prelimbic cortex. eLife Sciences Publications, Ltd 2019-05-14 /pmc/articles/PMC6516825/ /pubmed/31084703 http://dx.doi.org/10.7554/eLife.44026 Text en © 2019, He et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience He, Zhixiong Young, Larry Ma, Xin-Ming Guo, Qianqian Wang, Limin Yang, Yang Luo, Luo Yuan, Wei Li, Laifu Zhang, Jing Hou, Wenjuan Qiao, Hui Jia, Rui Tai, Fadao Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway |
title | Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway |
title_full | Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway |
title_fullStr | Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway |
title_full_unstemmed | Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway |
title_short | Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway |
title_sort | increased anxiety and decreased sociability induced by paternal deprivation involve the pvn-prl otergic pathway |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516825/ https://www.ncbi.nlm.nih.gov/pubmed/31084703 http://dx.doi.org/10.7554/eLife.44026 |
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