IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we performed proteomic, transcriptomic, and electron microscopic analyses to demonstrate that mast cells are aberrantly activated in human and...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Lepus, Christin M, Raghu, Harini, Reber, Laurent L, Tsai, Mindy M, Wong, Heidi H, von Kaeppler, Ericka, Lingampalli, Nithya, Bloom, Michelle S, Hu, Nick, Elliott, Eileen E, Oliviero, Francesca, Punzi, Leonardo, Giori, Nicholas J, Goodman, Stuart B, Chu, Constance R, Sokolove, Jeremy, Fukuoka, Yoshihiro, Schwartz, Lawrence B, Galli, Stephen J, Robinson, William H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516833/
https://www.ncbi.nlm.nih.gov/pubmed/31084709
http://dx.doi.org/10.7554/eLife.39905

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