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Independent amylase gene copy number bursts correlate with dietary preferences in mammals

The amylase gene (AMY), which codes for a starch-digesting enzyme in animals, underwent several gene copy number gains in humans (Perry et al., 2007), dogs (Axelsson et al., 2013), and mice (Schibler et al., 1982), possibly along with increased starch consumption during the evolution of these specie...

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Autores principales: Pajic, Petar, Pavlidis, Pavlos, Dean, Kirsten, Neznanova, Lubov, Romano, Rose-Anne, Garneau, Danielle, Daugherity, Erin, Globig, Anja, Ruhl, Stefan, Gokcumen, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516957/
https://www.ncbi.nlm.nih.gov/pubmed/31084707
http://dx.doi.org/10.7554/eLife.44628
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author Pajic, Petar
Pavlidis, Pavlos
Dean, Kirsten
Neznanova, Lubov
Romano, Rose-Anne
Garneau, Danielle
Daugherity, Erin
Globig, Anja
Ruhl, Stefan
Gokcumen, Omer
author_facet Pajic, Petar
Pavlidis, Pavlos
Dean, Kirsten
Neznanova, Lubov
Romano, Rose-Anne
Garneau, Danielle
Daugherity, Erin
Globig, Anja
Ruhl, Stefan
Gokcumen, Omer
author_sort Pajic, Petar
collection PubMed
description The amylase gene (AMY), which codes for a starch-digesting enzyme in animals, underwent several gene copy number gains in humans (Perry et al., 2007), dogs (Axelsson et al., 2013), and mice (Schibler et al., 1982), possibly along with increased starch consumption during the evolution of these species. Here, we present comprehensive evidence for AMY copy number expansions that independently occurred in several mammalian species which consume diets rich in starch. We also provide correlative evidence that AMY gene duplications may be an essential first step for amylase to be expressed in saliva. Our findings underscore the overall importance of gene copy number amplification as a flexible and fast evolutionary mechanism that can independently occur in different branches of the phylogeny.
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spelling pubmed-65169572019-05-16 Independent amylase gene copy number bursts correlate with dietary preferences in mammals Pajic, Petar Pavlidis, Pavlos Dean, Kirsten Neznanova, Lubov Romano, Rose-Anne Garneau, Danielle Daugherity, Erin Globig, Anja Ruhl, Stefan Gokcumen, Omer eLife Evolutionary Biology The amylase gene (AMY), which codes for a starch-digesting enzyme in animals, underwent several gene copy number gains in humans (Perry et al., 2007), dogs (Axelsson et al., 2013), and mice (Schibler et al., 1982), possibly along with increased starch consumption during the evolution of these species. Here, we present comprehensive evidence for AMY copy number expansions that independently occurred in several mammalian species which consume diets rich in starch. We also provide correlative evidence that AMY gene duplications may be an essential first step for amylase to be expressed in saliva. Our findings underscore the overall importance of gene copy number amplification as a flexible and fast evolutionary mechanism that can independently occur in different branches of the phylogeny. eLife Sciences Publications, Ltd 2019-05-14 /pmc/articles/PMC6516957/ /pubmed/31084707 http://dx.doi.org/10.7554/eLife.44628 Text en © 2019, Pajic et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Pajic, Petar
Pavlidis, Pavlos
Dean, Kirsten
Neznanova, Lubov
Romano, Rose-Anne
Garneau, Danielle
Daugherity, Erin
Globig, Anja
Ruhl, Stefan
Gokcumen, Omer
Independent amylase gene copy number bursts correlate with dietary preferences in mammals
title Independent amylase gene copy number bursts correlate with dietary preferences in mammals
title_full Independent amylase gene copy number bursts correlate with dietary preferences in mammals
title_fullStr Independent amylase gene copy number bursts correlate with dietary preferences in mammals
title_full_unstemmed Independent amylase gene copy number bursts correlate with dietary preferences in mammals
title_short Independent amylase gene copy number bursts correlate with dietary preferences in mammals
title_sort independent amylase gene copy number bursts correlate with dietary preferences in mammals
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516957/
https://www.ncbi.nlm.nih.gov/pubmed/31084707
http://dx.doi.org/10.7554/eLife.44628
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