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Independent amylase gene copy number bursts correlate with dietary preferences in mammals
The amylase gene (AMY), which codes for a starch-digesting enzyme in animals, underwent several gene copy number gains in humans (Perry et al., 2007), dogs (Axelsson et al., 2013), and mice (Schibler et al., 1982), possibly along with increased starch consumption during the evolution of these specie...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516957/ https://www.ncbi.nlm.nih.gov/pubmed/31084707 http://dx.doi.org/10.7554/eLife.44628 |
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author | Pajic, Petar Pavlidis, Pavlos Dean, Kirsten Neznanova, Lubov Romano, Rose-Anne Garneau, Danielle Daugherity, Erin Globig, Anja Ruhl, Stefan Gokcumen, Omer |
author_facet | Pajic, Petar Pavlidis, Pavlos Dean, Kirsten Neznanova, Lubov Romano, Rose-Anne Garneau, Danielle Daugherity, Erin Globig, Anja Ruhl, Stefan Gokcumen, Omer |
author_sort | Pajic, Petar |
collection | PubMed |
description | The amylase gene (AMY), which codes for a starch-digesting enzyme in animals, underwent several gene copy number gains in humans (Perry et al., 2007), dogs (Axelsson et al., 2013), and mice (Schibler et al., 1982), possibly along with increased starch consumption during the evolution of these species. Here, we present comprehensive evidence for AMY copy number expansions that independently occurred in several mammalian species which consume diets rich in starch. We also provide correlative evidence that AMY gene duplications may be an essential first step for amylase to be expressed in saliva. Our findings underscore the overall importance of gene copy number amplification as a flexible and fast evolutionary mechanism that can independently occur in different branches of the phylogeny. |
format | Online Article Text |
id | pubmed-6516957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65169572019-05-16 Independent amylase gene copy number bursts correlate with dietary preferences in mammals Pajic, Petar Pavlidis, Pavlos Dean, Kirsten Neznanova, Lubov Romano, Rose-Anne Garneau, Danielle Daugherity, Erin Globig, Anja Ruhl, Stefan Gokcumen, Omer eLife Evolutionary Biology The amylase gene (AMY), which codes for a starch-digesting enzyme in animals, underwent several gene copy number gains in humans (Perry et al., 2007), dogs (Axelsson et al., 2013), and mice (Schibler et al., 1982), possibly along with increased starch consumption during the evolution of these species. Here, we present comprehensive evidence for AMY copy number expansions that independently occurred in several mammalian species which consume diets rich in starch. We also provide correlative evidence that AMY gene duplications may be an essential first step for amylase to be expressed in saliva. Our findings underscore the overall importance of gene copy number amplification as a flexible and fast evolutionary mechanism that can independently occur in different branches of the phylogeny. eLife Sciences Publications, Ltd 2019-05-14 /pmc/articles/PMC6516957/ /pubmed/31084707 http://dx.doi.org/10.7554/eLife.44628 Text en © 2019, Pajic et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Evolutionary Biology Pajic, Petar Pavlidis, Pavlos Dean, Kirsten Neznanova, Lubov Romano, Rose-Anne Garneau, Danielle Daugherity, Erin Globig, Anja Ruhl, Stefan Gokcumen, Omer Independent amylase gene copy number bursts correlate with dietary preferences in mammals |
title | Independent amylase gene copy number bursts correlate with dietary preferences in mammals |
title_full | Independent amylase gene copy number bursts correlate with dietary preferences in mammals |
title_fullStr | Independent amylase gene copy number bursts correlate with dietary preferences in mammals |
title_full_unstemmed | Independent amylase gene copy number bursts correlate with dietary preferences in mammals |
title_short | Independent amylase gene copy number bursts correlate with dietary preferences in mammals |
title_sort | independent amylase gene copy number bursts correlate with dietary preferences in mammals |
topic | Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516957/ https://www.ncbi.nlm.nih.gov/pubmed/31084707 http://dx.doi.org/10.7554/eLife.44628 |
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