Cargando…

Gender differences in cancer risk after kidney transplantation

Kidney transplant (KT) recipients are at greater risk of developing some cancers than the general population. Moreover, cancer is the only cause of death that is currently increasing after kidney transplantation. We analyzed incidence, risk factors and characteristics of post-transplant malignancies...

Descripción completa

Detalles Bibliográficos
Autores principales: Buxeda, Anna, Redondo-Pachón, Dolores, Pérez-Sáez, María José, Bartolomé, Álvaro, Mir, Marisa, Pascual-Dapena, Ana, Sans, Anna, Duran, Xavier, Crespo, Marta, Pascual, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517099/
https://www.ncbi.nlm.nih.gov/pubmed/31139324
http://dx.doi.org/10.18632/oncotarget.26859
_version_ 1783418244183359488
author Buxeda, Anna
Redondo-Pachón, Dolores
Pérez-Sáez, María José
Bartolomé, Álvaro
Mir, Marisa
Pascual-Dapena, Ana
Sans, Anna
Duran, Xavier
Crespo, Marta
Pascual, Julio
author_facet Buxeda, Anna
Redondo-Pachón, Dolores
Pérez-Sáez, María José
Bartolomé, Álvaro
Mir, Marisa
Pascual-Dapena, Ana
Sans, Anna
Duran, Xavier
Crespo, Marta
Pascual, Julio
author_sort Buxeda, Anna
collection PubMed
description Kidney transplant (KT) recipients are at greater risk of developing some cancers than the general population. Moreover, cancer is the only cause of death that is currently increasing after kidney transplantation. We analyzed incidence, risk factors and characteristics of post-transplant malignancies (solid organ tumors and lymphoproliferative disorders) at our center in 925 KT recipients (1979-2014). Sex differences were particularly assessed. One hundred and eight patients (11.7%) developed solid organ tumors (76.9%) or lymphoma (23.1%). Twenty-one percent of patients who reached 20 years after KT developed cancer, with a median post-KT time to diagnosis of 7.4 years. Most common solid organs affected were lung (30.1%), prostate (10.8%), bladder (9.6%), and native kidney (7.2%). When analyzing standardized incidence ratios (SIR) by gender compared to the general population, relative risk was increased in women (SIR = 1.81; 95%CI, 1.28–2.45) but not significantly increased in men (SIR = 1.22; 0.95–2.52). Regarding specific types, gynecological (SIR = 11.6; 4.2–22.7) and lung (SIR = 10.0; 4.3–18.2) in women, and bladder (SIR = 16.3; 5.9–32.1) in men were the most affected locations. Thymoglobulin, a polyclonal antibody that has been used as an immunosuppressive agent in kidney transplantation over the last decades, was a significant risk factor for developing cancer in adjusted regression analysis [IRR = 1.62, 1.02–2.57; p = 0.041], and was associated with lower patient survival. Compared with the general population, the incidence of post-KT non-skin cancer is almost two-fold higher in women but not significantly higher in men. Lung is the most common solid organ affected. Thymoglobulin induction therapy is associated with a greater risk.
format Online
Article
Text
id pubmed-6517099
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-65170992019-05-28 Gender differences in cancer risk after kidney transplantation Buxeda, Anna Redondo-Pachón, Dolores Pérez-Sáez, María José Bartolomé, Álvaro Mir, Marisa Pascual-Dapena, Ana Sans, Anna Duran, Xavier Crespo, Marta Pascual, Julio Oncotarget Research Paper Kidney transplant (KT) recipients are at greater risk of developing some cancers than the general population. Moreover, cancer is the only cause of death that is currently increasing after kidney transplantation. We analyzed incidence, risk factors and characteristics of post-transplant malignancies (solid organ tumors and lymphoproliferative disorders) at our center in 925 KT recipients (1979-2014). Sex differences were particularly assessed. One hundred and eight patients (11.7%) developed solid organ tumors (76.9%) or lymphoma (23.1%). Twenty-one percent of patients who reached 20 years after KT developed cancer, with a median post-KT time to diagnosis of 7.4 years. Most common solid organs affected were lung (30.1%), prostate (10.8%), bladder (9.6%), and native kidney (7.2%). When analyzing standardized incidence ratios (SIR) by gender compared to the general population, relative risk was increased in women (SIR = 1.81; 95%CI, 1.28–2.45) but not significantly increased in men (SIR = 1.22; 0.95–2.52). Regarding specific types, gynecological (SIR = 11.6; 4.2–22.7) and lung (SIR = 10.0; 4.3–18.2) in women, and bladder (SIR = 16.3; 5.9–32.1) in men were the most affected locations. Thymoglobulin, a polyclonal antibody that has been used as an immunosuppressive agent in kidney transplantation over the last decades, was a significant risk factor for developing cancer in adjusted regression analysis [IRR = 1.62, 1.02–2.57; p = 0.041], and was associated with lower patient survival. Compared with the general population, the incidence of post-KT non-skin cancer is almost two-fold higher in women but not significantly higher in men. Lung is the most common solid organ affected. Thymoglobulin induction therapy is associated with a greater risk. Impact Journals LLC 2019-05-03 /pmc/articles/PMC6517099/ /pubmed/31139324 http://dx.doi.org/10.18632/oncotarget.26859 Text en Copyright: © 2019 Buxeda et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Buxeda, Anna
Redondo-Pachón, Dolores
Pérez-Sáez, María José
Bartolomé, Álvaro
Mir, Marisa
Pascual-Dapena, Ana
Sans, Anna
Duran, Xavier
Crespo, Marta
Pascual, Julio
Gender differences in cancer risk after kidney transplantation
title Gender differences in cancer risk after kidney transplantation
title_full Gender differences in cancer risk after kidney transplantation
title_fullStr Gender differences in cancer risk after kidney transplantation
title_full_unstemmed Gender differences in cancer risk after kidney transplantation
title_short Gender differences in cancer risk after kidney transplantation
title_sort gender differences in cancer risk after kidney transplantation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517099/
https://www.ncbi.nlm.nih.gov/pubmed/31139324
http://dx.doi.org/10.18632/oncotarget.26859
work_keys_str_mv AT buxedaanna genderdifferencesincancerriskafterkidneytransplantation
AT redondopachondolores genderdifferencesincancerriskafterkidneytransplantation
AT perezsaezmariajose genderdifferencesincancerriskafterkidneytransplantation
AT bartolomealvaro genderdifferencesincancerriskafterkidneytransplantation
AT mirmarisa genderdifferencesincancerriskafterkidneytransplantation
AT pascualdapenaana genderdifferencesincancerriskafterkidneytransplantation
AT sansanna genderdifferencesincancerriskafterkidneytransplantation
AT duranxavier genderdifferencesincancerriskafterkidneytransplantation
AT crespomarta genderdifferencesincancerriskafterkidneytransplantation
AT pascualjulio genderdifferencesincancerriskafterkidneytransplantation