Aminophylline shortage and current recommendations for reversal of vasodilator stress: An ASNC information statement endorsed by SCMR

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Pharmacologic reversal of serious or intolerable side effects (SISEs) from vasodilator stress is an important safety and comfort measure for patients experiencing such effects. While typically performed using intravenous aminophylline, recurrent shortages of this agent have led to a greater need to...

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Detalles Bibliográficos
Autores principales: Abidov, Aiden, Dilsizian, Vasken, Doukky, Rami, Duvall, W. Lane, Dyke, Christopher, Elliott, Michael D., Hage, Fadi G., Henzlova, Milena J., Johnson, Nils P., Schwartz, Ronald G., Thomas, Gregory S., Einstein, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
ASNC Information Statement
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517353/
https://www.ncbi.nlm.nih.gov/pubmed/30574677
http://dx.doi.org/10.1007/s12350-018-01548-0
Descripción
Sumario:Pharmacologic reversal of serious or intolerable side effects (SISEs) from vasodilator stress is an important safety and comfort measure for patients experiencing such effects. While typically performed using intravenous aminophylline, recurrent shortages of this agent have led to a greater need to limit its use and consider alternative agents. This information statement provides background and recommendations addressing indications for vasodilator reversal, timing of a reversal agent, incidence of observed SISE with vasodilator stress, clinical and logistical considerations for aminophylline-based reversal, and alternative non-aminophylline based reversal protocols. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12350-018-01548-0) contains supplementary material, which is available to authorized users.

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