miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate

T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8(+) T cell antitumor function by restraining T cell senescence and functional exhaustion through epigenetic silencing of drivers of terminal differentiation. miR-155 enhance...

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Detalles Bibliográficos
Autores principales: Ji, Yun, Fioravanti, Jessica, Zhu, Wei, Wang, Hongjun, Wu, Tuoqi, Hu, Jinhui, Lacey, Neal E., Gautam, Sanjivan, Le Gall, John B., Yang, Xia, Hocker, James D., Escobar, Thelma M., He, Shan, Dell’Orso, Stefania, Hawk, Nga V., Kapoor, Veena, Telford, William G., Di Croce, Luciano, Muljo, Stefan A., Zhang, Yi, Sartorelli, Vittorio, Gattinoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517388/
https://www.ncbi.nlm.nih.gov/pubmed/31089138
http://dx.doi.org/10.1038/s41467-019-09882-8

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