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Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study
BACKGROUND: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study c...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517452/ https://www.ncbi.nlm.nih.gov/pubmed/31089908 http://dx.doi.org/10.1186/s13613-019-0529-4 |
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author | Schouten, Laura R. van Kaam, Anton H. Kohse, Franziska Veltkamp, Floor Bos, Lieuwe D. de Beer, Friso M. van Hooijdonk, Roosmarijn T. Horn, Janneke Straat, Marleen Witteveen, Esther Glas, Gerie J. Wieske, Luuk van Vught, Lonneke A. Wiewel, Maryse A. Ingelse, Sarah A. Cortjens, Bart van Woensel, Job B. Bos, Albert P. Walther, Thomas Schultz, Marcus J. Wösten-van Asperen, Roelie M. |
author_facet | Schouten, Laura R. van Kaam, Anton H. Kohse, Franziska Veltkamp, Floor Bos, Lieuwe D. de Beer, Friso M. van Hooijdonk, Roosmarijn T. Horn, Janneke Straat, Marleen Witteveen, Esther Glas, Gerie J. Wieske, Luuk van Vught, Lonneke A. Wiewel, Maryse A. Ingelse, Sarah A. Cortjens, Bart van Woensel, Job B. Bos, Albert P. Walther, Thomas Schultz, Marcus J. Wösten-van Asperen, Roelie M. |
author_sort | Schouten, Laura R. |
collection | PubMed |
description | BACKGROUND: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. METHODS: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. RESULTS: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. CONCLUSIONS: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13613-019-0529-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6517452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-65174522019-05-29 Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study Schouten, Laura R. van Kaam, Anton H. Kohse, Franziska Veltkamp, Floor Bos, Lieuwe D. de Beer, Friso M. van Hooijdonk, Roosmarijn T. Horn, Janneke Straat, Marleen Witteveen, Esther Glas, Gerie J. Wieske, Luuk van Vught, Lonneke A. Wiewel, Maryse A. Ingelse, Sarah A. Cortjens, Bart van Woensel, Job B. Bos, Albert P. Walther, Thomas Schultz, Marcus J. Wösten-van Asperen, Roelie M. Ann Intensive Care Research BACKGROUND: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. METHODS: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. RESULTS: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. CONCLUSIONS: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13613-019-0529-4) contains supplementary material, which is available to authorized users. Springer International Publishing 2019-05-14 /pmc/articles/PMC6517452/ /pubmed/31089908 http://dx.doi.org/10.1186/s13613-019-0529-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Schouten, Laura R. van Kaam, Anton H. Kohse, Franziska Veltkamp, Floor Bos, Lieuwe D. de Beer, Friso M. van Hooijdonk, Roosmarijn T. Horn, Janneke Straat, Marleen Witteveen, Esther Glas, Gerie J. Wieske, Luuk van Vught, Lonneke A. Wiewel, Maryse A. Ingelse, Sarah A. Cortjens, Bart van Woensel, Job B. Bos, Albert P. Walther, Thomas Schultz, Marcus J. Wösten-van Asperen, Roelie M. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study |
title | Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study |
title_full | Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study |
title_fullStr | Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study |
title_full_unstemmed | Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study |
title_short | Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study |
title_sort | age-dependent differences in pulmonary host responses in ards: a prospective observational cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517452/ https://www.ncbi.nlm.nih.gov/pubmed/31089908 http://dx.doi.org/10.1186/s13613-019-0529-4 |
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