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The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits

AIM: It is reported that hyperlipidemia affects quality and density of bone and adversely affects wound healing. The effect of hyperlipidemia on implant osseointegration and peri-implant defect regeneration has not been fully explained. The purpose of this study was to examine the effects of hyperli...

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Autores principales: Tekin, Mehmet Bugrul, Toker, Hulya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517464/
https://www.ncbi.nlm.nih.gov/pubmed/31089911
http://dx.doi.org/10.1186/s40729-019-0170-x
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author Tekin, Mehmet Bugrul
Toker, Hulya
author_facet Tekin, Mehmet Bugrul
Toker, Hulya
author_sort Tekin, Mehmet Bugrul
collection PubMed
description AIM: It is reported that hyperlipidemia affects quality and density of bone and adversely affects wound healing. The effect of hyperlipidemia on implant osseointegration and peri-implant defect regeneration has not been fully explained. The purpose of this study was to examine the effects of hyperlipidemia on the healing potential of the materials used for peri-implant bone regeneration and implant stability. MATERIALS AND METHODS: Twelve male, New Zealand rabbits were used in this study. Half of the rabbits were fed a 2% cholesterol diet for 8 weeks to induce hypercholesterolemia. Peri-implant defects (7 mm diameter) were created in the tibias of rabbits and placed implants (3.3 mm in diameter). This study was conducted as a split-mouth design. Animals were randomly divided into two groups: (1) hypercholesterol+autogenous graft group and hypercholesterol+xenograft group (n = 6), and (2) autogenous graft and xenograft groups as controls (n = 6). At 8 weeks after surgery, the rabbits were euthanized. During implant surgery and at 8 weeks, implant stability was measured with resonance frequency analysis (RFA values). Bone-to-implant contact (BIC) was analyzed via histomorphometric analysis. RESULTS: Hyperlipidemic groups showed significantly lower BIC values than those of the control groups at 8 weeks (p < 0.05). According to baseline RFA readings, there was no significant difference between control and hyperlipidemic groups (p ˃ 0.05). The hypercholesterol+autogenous graft group had significantly lower RFA readings and BIC values than the hypercholesterol+xenograft group at 8 weeks (p < 0.05). CONCLUSION: Within the limitations of this study, it was found that hyperlipidemia may negatively affect the implant stability especially in the autogenous group and also, may decrease peri-implant bone regeneration. However, further studies are necessary to confirm these results more.
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spelling pubmed-65174642019-05-29 The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits Tekin, Mehmet Bugrul Toker, Hulya Int J Implant Dent Research AIM: It is reported that hyperlipidemia affects quality and density of bone and adversely affects wound healing. The effect of hyperlipidemia on implant osseointegration and peri-implant defect regeneration has not been fully explained. The purpose of this study was to examine the effects of hyperlipidemia on the healing potential of the materials used for peri-implant bone regeneration and implant stability. MATERIALS AND METHODS: Twelve male, New Zealand rabbits were used in this study. Half of the rabbits were fed a 2% cholesterol diet for 8 weeks to induce hypercholesterolemia. Peri-implant defects (7 mm diameter) were created in the tibias of rabbits and placed implants (3.3 mm in diameter). This study was conducted as a split-mouth design. Animals were randomly divided into two groups: (1) hypercholesterol+autogenous graft group and hypercholesterol+xenograft group (n = 6), and (2) autogenous graft and xenograft groups as controls (n = 6). At 8 weeks after surgery, the rabbits were euthanized. During implant surgery and at 8 weeks, implant stability was measured with resonance frequency analysis (RFA values). Bone-to-implant contact (BIC) was analyzed via histomorphometric analysis. RESULTS: Hyperlipidemic groups showed significantly lower BIC values than those of the control groups at 8 weeks (p < 0.05). According to baseline RFA readings, there was no significant difference between control and hyperlipidemic groups (p ˃ 0.05). The hypercholesterol+autogenous graft group had significantly lower RFA readings and BIC values than the hypercholesterol+xenograft group at 8 weeks (p < 0.05). CONCLUSION: Within the limitations of this study, it was found that hyperlipidemia may negatively affect the implant stability especially in the autogenous group and also, may decrease peri-implant bone regeneration. However, further studies are necessary to confirm these results more. Springer Berlin Heidelberg 2019-05-15 /pmc/articles/PMC6517464/ /pubmed/31089911 http://dx.doi.org/10.1186/s40729-019-0170-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Tekin, Mehmet Bugrul
Toker, Hulya
The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits
title The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits
title_full The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits
title_fullStr The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits
title_full_unstemmed The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits
title_short The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits
title_sort effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517464/
https://www.ncbi.nlm.nih.gov/pubmed/31089911
http://dx.doi.org/10.1186/s40729-019-0170-x
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