Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid

Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three diff...

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Detalles Bibliográficos
Autores principales: Nieto Ramirez, Luisa María, Mehaffy, Carolina, Dobos, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Proteomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517567/
https://www.ncbi.nlm.nih.gov/pubmed/31193076
http://dx.doi.org/10.1016/j.dib.2019.103953
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author Nieto Ramirez, Luisa María
Mehaffy, Carolina
Dobos, Karen M.
author_facet Nieto Ramirez, Luisa María
Mehaffy, Carolina
Dobos, Karen M.
author_sort Nieto Ramirez, Luisa María
collection PubMed
description Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three different variables: cellular fraction, genetic lineage, and INH phenotypic profile. Mass spectrometry analysis demonstrated that the most significantly affected cellular fraction was the membrane and the INH resistant strains showed the highest number of proteins altered when they were exposed to INH. Raw data are available via ProteomeXchange with identifier PXD007588.
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spelling pubmed-65175672019-05-21 Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid Nieto Ramirez, Luisa María Mehaffy, Carolina Dobos, Karen M. Data Brief Proteomics Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three different variables: cellular fraction, genetic lineage, and INH phenotypic profile. Mass spectrometry analysis demonstrated that the most significantly affected cellular fraction was the membrane and the INH resistant strains showed the highest number of proteins altered when they were exposed to INH. Raw data are available via ProteomeXchange with identifier PXD007588. Elsevier 2019-04-25 /pmc/articles/PMC6517567/ /pubmed/31193076 http://dx.doi.org/10.1016/j.dib.2019.103953 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Proteomics
Nieto Ramirez, Luisa María
Mehaffy, Carolina
Dobos, Karen M.
Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid
title Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid
title_full Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid
title_fullStr Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid
title_full_unstemmed Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid
title_short Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid
title_sort protein profile of different cellular fractions from mycobacterium tuberculosis strains after exposure to isoniazid
topic Proteomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517567/
https://www.ncbi.nlm.nih.gov/pubmed/31193076
http://dx.doi.org/10.1016/j.dib.2019.103953
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